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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NTHL1
All Species:
9.7
Human Site:
S53
Identified Species:
16.41
UniProt:
P78549
Number Species:
13
Phosphosite Substitution
Charge Score:
-0.23
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78549
NP_002519.1
312
34390
S53
A
E
A
R
K
S
H
S
P
V
K
R
P
R
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001082772
312
34406
S53
A
E
A
R
K
S
H
S
P
V
K
R
R
R
K
Dog
Lupus familis
XP_853674
312
34244
S53
A
E
G
K
K
N
P
S
L
A
K
R
Q
R
K
Cat
Felis silvestris
Mouse
Mus musculus
O35980
300
33628
R41
A
E
G
R
K
S
H
R
P
V
R
H
P
R
R
Rat
Rattus norvegicus
O70249
345
38693
R46
L
A
S
G
Q
S
F
R
W
R
E
Q
S
P
A
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517653
262
28773
K41
E
A
Q
V
R
P
L
K
R
Q
R
R
R
P
K
Chicken
Gallus gallus
NP_001073043
281
31866
I41
R
R
T
R
R
V
P
I
A
Y
E
A
E
P
K
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001346643
430
48207
N77
D
D
P
T
H
A
H
N
P
A
D
C
V
K
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610078
388
43493
S59
S
S
S
S
V
F
F
S
P
V
Q
T
R
K
Q
Honey Bee
Apis mellifera
XP_623602
321
36892
E57
T
P
V
K
I
K
Y
E
E
M
E
N
I
T
D
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793669
395
44330
V110
G
K
S
K
R
S
L
V
Q
K
Q
R
V
G
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001151454
364
40315
V58
T
P
K
P
E
A
T
V
S
V
K
R
R
R
V
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_001077988
377
41467
K69
T
R
V
Y
T
R
K
K
R
L
K
Q
E
P
F
Baker's Yeast
Sacchar. cerevisiae
P31378
399
45558
A101
Y
K
F
Q
E
T
Y
A
R
M
R
V
L
R
S
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.9
79.4
N.A.
78.8
20.8
N.A.
50.9
63.4
N.A.
42.7
N.A.
40.7
46.1
N.A.
43.5
Protein Similarity:
100
N.A.
95.5
86.2
N.A.
84.9
33
N.A.
60.5
73.4
N.A.
52.3
N.A.
53
59.5
N.A.
56.9
P-Site Identity:
100
N.A.
93.3
53.3
N.A.
66.6
6.6
N.A.
13.3
13.3
N.A.
13.3
N.A.
20
0
N.A.
20
P-Site Similarity:
100
N.A.
93.3
66.6
N.A.
80
33.3
N.A.
26.6
26.6
N.A.
40
N.A.
53.3
26.6
N.A.
53.3
Percent
Protein Identity:
N.A.
38.7
N.A.
38.4
31
N.A.
Protein Similarity:
N.A.
53.3
N.A.
52.5
43.8
N.A.
P-Site Identity:
N.A.
26.6
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
40
N.A.
20
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
29
15
15
0
0
15
0
8
8
15
0
8
0
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
8
0
0
0
% C
% Asp:
8
8
0
0
0
0
0
0
0
0
8
0
0
0
8
% D
% Glu:
8
29
0
0
15
0
0
8
8
0
22
0
15
0
0
% E
% Phe:
0
0
8
0
0
8
15
0
0
0
0
0
0
0
8
% F
% Gly:
8
0
15
8
0
0
0
0
0
0
0
0
0
8
0
% G
% His:
0
0
0
0
8
0
29
0
0
0
0
8
0
0
0
% H
% Ile:
0
0
0
0
8
0
0
8
0
0
0
0
8
0
0
% I
% Lys:
0
15
8
22
29
8
8
15
0
8
36
0
0
15
43
% K
% Leu:
8
0
0
0
0
0
15
0
8
8
0
0
8
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
15
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
8
0
8
0
0
0
8
0
0
0
% N
% Pro:
0
15
8
8
0
8
15
0
36
0
0
0
15
29
0
% P
% Gln:
0
0
8
8
8
0
0
0
8
8
15
15
8
0
8
% Q
% Arg:
8
15
0
29
22
8
0
15
22
8
22
43
29
43
8
% R
% Ser:
8
8
22
8
0
36
0
29
8
0
0
0
8
0
15
% S
% Thr:
22
0
8
8
8
8
8
0
0
0
0
8
0
8
0
% T
% Val:
0
0
15
8
8
8
0
15
0
36
0
8
15
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% W
% Tyr:
8
0
0
8
0
0
15
0
0
8
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _