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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NTHL1
All Species:
19.7
Human Site:
Y119
Identified Species:
33.33
UniProt:
P78549
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78549
NP_002519.1
312
34390
Y119
H
L
G
T
E
H
C
Y
D
S
S
A
P
P
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001082772
312
34406
Y119
H
L
G
V
E
H
C
Y
D
S
S
A
P
P
K
Dog
Lupus familis
XP_853674
312
34244
H119
W
L
G
V
E
H
C
H
D
P
S
A
P
P
K
Cat
Felis silvestris
Mouse
Mus musculus
O35980
300
33628
Y107
Q
L
G
A
E
H
C
Y
D
A
S
A
P
P
K
Rat
Rattus norvegicus
O70249
345
38693
Y99
E
L
E
T
L
H
K
Y
F
Q
L
D
V
S
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517653
262
28773
S95
N
I
R
D
K
R
E
S
R
D
A
P
V
D
Q
Chicken
Gallus gallus
NP_001073043
281
31866
Y88
E
M
G
V
D
K
C
Y
D
T
S
A
P
P
Q
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001346643
430
48207
Y157
Q
M
G
A
E
K
C
Y
D
T
Q
G
L
P
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610078
388
43493
A186
T
M
G
C
H
R
C
A
D
L
K
A
D
S
K
Honey Bee
Apis mellifera
XP_623602
321
36892
T120
E
M
G
C
H
K
C
T
D
P
K
A
T
A
K
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793669
395
44330
C182
S
M
G
A
E
K
I
C
D
S
S
A
A
P
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001151454
364
40315
G152
T
K
G
C
E
K
A
G
S
L
L
P
P
K
E
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_001077988
377
41467
G162
S
M
G
C
D
K
A
G
S
F
L
P
P
T
E
Baker's Yeast
Sacchar. cerevisiae
P31378
399
45558
Y142
E
Q
I
S
P
R
D
Y
R
L
Q
V
L
L
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.9
79.4
N.A.
78.8
20.8
N.A.
50.9
63.4
N.A.
42.7
N.A.
40.7
46.1
N.A.
43.5
Protein Similarity:
100
N.A.
95.5
86.2
N.A.
84.9
33
N.A.
60.5
73.4
N.A.
52.3
N.A.
53
59.5
N.A.
56.9
P-Site Identity:
100
N.A.
93.3
73.3
N.A.
80
26.6
N.A.
0
53.3
N.A.
40
N.A.
33.3
33.3
N.A.
46.6
P-Site Similarity:
100
N.A.
93.3
80
N.A.
86.6
26.6
N.A.
33.3
80
N.A.
60
N.A.
40
40
N.A.
60
Percent
Protein Identity:
N.A.
38.7
N.A.
38.4
31
N.A.
Protein Similarity:
N.A.
53.3
N.A.
52.5
43.8
N.A.
P-Site Identity:
N.A.
20
N.A.
13.3
6.6
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
33.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
22
0
0
15
8
0
8
8
58
8
8
0
% A
% Cys:
0
0
0
29
0
0
58
8
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
8
15
0
8
0
65
8
0
8
8
8
0
% D
% Glu:
29
0
8
0
50
0
8
0
0
0
0
0
0
0
29
% E
% Phe:
0
0
0
0
0
0
0
0
8
8
0
0
0
0
0
% F
% Gly:
0
0
79
0
0
0
0
15
0
0
0
8
0
0
8
% G
% His:
15
0
0
0
15
36
0
8
0
0
0
0
0
0
0
% H
% Ile:
0
8
8
0
0
0
8
0
0
0
0
0
0
0
0
% I
% Lys:
0
8
0
0
8
43
8
0
0
0
15
0
0
8
43
% K
% Leu:
0
36
0
0
8
0
0
0
0
22
22
0
15
8
8
% L
% Met:
0
43
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
8
0
0
0
0
15
0
22
50
50
0
% P
% Gln:
15
8
0
0
0
0
0
0
0
8
15
0
0
0
15
% Q
% Arg:
0
0
8
0
0
22
0
0
15
0
0
0
0
0
0
% R
% Ser:
15
0
0
8
0
0
0
8
15
22
43
0
0
15
0
% S
% Thr:
15
0
0
15
0
0
0
8
0
15
0
0
8
8
0
% T
% Val:
0
0
0
22
0
0
0
0
0
0
0
8
15
0
0
% V
% Trp:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
50
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _