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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NTHL1
All Species:
26.67
Human Site:
Y200
Identified Species:
45.13
UniProt:
P78549
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P78549
NP_002519.1
312
34390
Y200
S
A
I
L
Q
Q
H
Y
G
G
D
I
P
A
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001082772
312
34406
Y200
S
T
I
L
Q
Q
R
Y
G
G
D
I
P
A
S
Dog
Lupus familis
XP_853674
312
34244
Y200
S
A
I
L
Q
Q
R
Y
G
G
D
I
P
A
S
Cat
Felis silvestris
Mouse
Mus musculus
O35980
300
33628
Y188
T
A
I
L
Q
Q
R
Y
E
G
D
I
P
A
S
Rat
Rattus norvegicus
O70249
345
38693
G180
L
D
D
V
T
Y
H
G
F
P
N
L
H
A
L
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001517653
262
28773
V176
V
G
F
W
K
S
K
V
R
F
I
K
Q
T
T
Chicken
Gallus gallus
NP_001073043
281
31866
Y169
T
A
I
L
K
Q
K
Y
G
G
D
I
P
G
T
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001346643
430
48207
F238
T
A
L
I
Q
Q
E
F
G
G
D
I
P
N
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_610078
388
43493
Y267
V
E
I
L
T
D
K
Y
G
S
D
I
P
D
N
Honey Bee
Apis mellifera
XP_623602
321
36892
Y201
T
T
I
L
I
D
K
Y
D
S
D
I
P
K
T
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_793669
395
44330
Y263
T
Q
I
L
K
D
Q
Y
Q
G
D
I
P
P
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001151454
364
40315
F233
S
K
I
C
L
E
R
F
G
G
D
I
P
D
S
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
NP_001077988
377
41467
Y243
A
R
I
C
L
V
K
Y
D
G
D
I
P
S
S
Baker's Yeast
Sacchar. cerevisiae
P31378
399
45558
F223
C
K
I
L
Q
D
Q
F
S
S
D
V
P
A
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
93.9
79.4
N.A.
78.8
20.8
N.A.
50.9
63.4
N.A.
42.7
N.A.
40.7
46.1
N.A.
43.5
Protein Similarity:
100
N.A.
95.5
86.2
N.A.
84.9
33
N.A.
60.5
73.4
N.A.
52.3
N.A.
53
59.5
N.A.
56.9
P-Site Identity:
100
N.A.
86.6
93.3
N.A.
80
13.3
N.A.
0
66.6
N.A.
53.3
N.A.
46.6
40
N.A.
53.3
P-Site Similarity:
100
N.A.
86.6
93.3
N.A.
86.6
33.3
N.A.
13.3
86.6
N.A.
86.6
N.A.
53.3
53.3
N.A.
66.6
Percent
Protein Identity:
N.A.
38.7
N.A.
38.4
31
N.A.
Protein Similarity:
N.A.
53.3
N.A.
52.5
43.8
N.A.
P-Site Identity:
N.A.
53.3
N.A.
46.6
40
N.A.
P-Site Similarity:
N.A.
66.6
N.A.
60
60
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
36
0
0
0
0
0
0
0
0
0
0
0
43
0
% A
% Cys:
8
0
0
15
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
8
8
0
0
29
0
0
15
0
86
0
0
15
0
% D
% Glu:
0
8
0
0
0
8
8
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
8
0
0
0
0
22
8
8
0
0
0
0
0
% F
% Gly:
0
8
0
0
0
0
0
8
50
65
0
0
0
8
0
% G
% His:
0
0
0
0
0
0
15
0
0
0
0
0
8
0
0
% H
% Ile:
0
0
79
8
8
0
0
0
0
0
8
79
0
0
0
% I
% Lys:
0
15
0
0
22
0
36
0
0
0
0
8
0
8
0
% K
% Leu:
8
0
8
65
15
0
0
0
0
0
0
8
0
0
8
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
8
0
0
8
8
% N
% Pro:
0
0
0
0
0
0
0
0
0
8
0
0
86
8
0
% P
% Gln:
0
8
0
0
43
43
15
0
8
0
0
0
8
0
0
% Q
% Arg:
0
8
0
0
0
0
29
0
8
0
0
0
0
0
0
% R
% Ser:
29
0
0
0
0
8
0
0
8
22
0
0
0
8
50
% S
% Thr:
36
15
0
0
15
0
0
0
0
0
0
0
0
8
36
% T
% Val:
15
0
0
8
0
8
0
8
0
0
0
8
0
0
0
% V
% Trp:
0
0
0
8
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
8
0
65
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _