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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PHEX All Species: 17.47
Human Site: S7 Identified Species: 34.94
UniProt: P78562 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78562 NP_000435.3 749 86474 S7 _ M E A E T G S S V E T G K K
Chimpanzee Pan troglodytes XP_520972 749 86557 S7 _ M E A E T G S S V E T G K K
Rhesus Macaque Macaca mulatta XP_001087261 749 86532 S7 _ M E A E T G S S V E T G K R
Dog Lupus familis XP_537979 749 86353 S7 _ M E T E M G S S A E T G K T
Cat Felis silvestris
Mouse Mus musculus P70669 749 86400 S7 _ M E A E T G S T M E T G K G
Rat Rattus norvegicus P0C1T0 774 89178 M38 V L L T L L L M G A I V T L G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513691 751 86657 A9 E A E A A Q K A S L G T G K K
Chicken Gallus gallus XP_416801 716 82946 S9 E G E T V P A S R R A A N K A
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001082818 458 53118
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392502 776 89056 N55 T V L Q H P G N R R K S L G I
Nematode Worm Caenorhab. elegans O16796 848 97043 H114 D H A T Q T E H A G F G D P T
Sea Urchin Strong. purpuratus XP_781407 763 86739 V36 V I T R N L V V I V V V L A L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.4 98.6 95.1 N.A. 95.9 37.5 N.A. 88.5 78.2 N.A. 41.1 N.A. N.A. 37.1 31.9 38.4
Protein Similarity: 100 98.5 100 97.4 N.A. 98.6 58.7 N.A. 94.9 87.8 N.A. 51.4 N.A. N.A. 57.3 51.6 57.6
P-Site Identity: 100 100 92.8 71.4 N.A. 78.5 0 N.A. 46.6 20 N.A. 0 N.A. N.A. 6.6 6.6 6.6
P-Site Similarity: 100 100 100 71.4 N.A. 92.8 6.6 N.A. 60 20 N.A. 0 N.A. N.A. 33.3 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 9 42 9 0 9 9 9 17 9 9 0 9 9 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % D
% Glu: 17 0 59 0 42 0 9 0 0 0 42 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % F
% Gly: 0 9 0 0 0 0 50 0 9 9 9 9 50 9 17 % G
% His: 0 9 0 0 9 0 0 9 0 0 0 0 0 0 0 % H
% Ile: 0 9 0 0 0 0 0 0 9 0 9 0 0 0 9 % I
% Lys: 0 0 0 0 0 0 9 0 0 0 9 0 0 59 25 % K
% Leu: 0 9 17 0 9 17 9 0 0 9 0 0 17 9 9 % L
% Met: 0 42 0 0 0 9 0 9 0 9 0 0 0 0 0 % M
% Asn: 0 0 0 0 9 0 0 9 0 0 0 0 9 0 0 % N
% Pro: 0 0 0 0 0 17 0 0 0 0 0 0 0 9 0 % P
% Gln: 0 0 0 9 9 9 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 9 0 0 0 0 17 17 0 0 0 0 9 % R
% Ser: 0 0 0 0 0 0 0 50 42 0 0 9 0 0 0 % S
% Thr: 9 0 9 34 0 42 0 0 9 0 0 50 9 0 17 % T
% Val: 17 9 0 0 9 0 9 9 0 34 9 17 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 42 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _