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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: PHEX All Species: 19.39
Human Site: S8 Identified Species: 38.79
UniProt: P78562 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.18
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P78562 NP_000435.3 749 86474 S8 M E A E T G S S V E T G K K A
Chimpanzee Pan troglodytes XP_520972 749 86557 S8 M E A E T G S S V E T G K K A
Rhesus Macaque Macaca mulatta XP_001087261 749 86532 S8 M E A E T G S S V E T G K R A
Dog Lupus familis XP_537979 749 86353 S8 M E T E M G S S A E T G K T A
Cat Felis silvestris
Mouse Mus musculus P70669 749 86400 T8 M E A E T G S T M E T G K G T
Rat Rattus norvegicus P0C1T0 774 89178 G39 L L T L L L M G A I V T L G V
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001513691 751 86657 S10 A E A A Q K A S L G T G K K S
Chicken Gallus gallus XP_416801 716 82946 R10 G E T V P A S R R A A N K A T
Frog Xenopus laevis
Zebra Danio Brachydanio rerio NP_001082818 458 53118
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera XP_392502 776 89056 R56 V L Q H P G N R R K S L G I T
Nematode Worm Caenorhab. elegans O16796 848 97043 A115 H A T Q T E H A G F G D P T E
Sea Urchin Strong. purpuratus XP_781407 763 86739 I37 I T R N L V V I V V V L A L L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 97.4 98.6 95.1 N.A. 95.9 37.5 N.A. 88.5 78.2 N.A. 41.1 N.A. N.A. 37.1 31.9 38.4
Protein Similarity: 100 98.5 100 97.4 N.A. 98.6 58.7 N.A. 94.9 87.8 N.A. 51.4 N.A. N.A. 57.3 51.6 57.6
P-Site Identity: 100 100 93.3 73.3 N.A. 73.3 0 N.A. 46.6 20 N.A. 0 N.A. N.A. 6.6 6.6 6.6
P-Site Similarity: 100 100 100 73.3 N.A. 86.6 6.6 N.A. 66.6 20 N.A. 0 N.A. N.A. 33.3 20 13.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 9 42 9 0 9 9 9 17 9 9 0 9 9 34 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % D
% Glu: 0 59 0 42 0 9 0 0 0 42 0 0 0 0 9 % E
% Phe: 0 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % F
% Gly: 9 0 0 0 0 50 0 9 9 9 9 50 9 17 0 % G
% His: 9 0 0 9 0 0 9 0 0 0 0 0 0 0 0 % H
% Ile: 9 0 0 0 0 0 0 9 0 9 0 0 0 9 0 % I
% Lys: 0 0 0 0 0 9 0 0 0 9 0 0 59 25 0 % K
% Leu: 9 17 0 9 17 9 0 0 9 0 0 17 9 9 9 % L
% Met: 42 0 0 0 9 0 9 0 9 0 0 0 0 0 0 % M
% Asn: 0 0 0 9 0 0 9 0 0 0 0 9 0 0 0 % N
% Pro: 0 0 0 0 17 0 0 0 0 0 0 0 9 0 0 % P
% Gln: 0 0 9 9 9 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 9 0 0 0 0 17 17 0 0 0 0 9 0 % R
% Ser: 0 0 0 0 0 0 50 42 0 0 9 0 0 0 9 % S
% Thr: 0 9 34 0 42 0 0 9 0 0 50 9 0 17 25 % T
% Val: 9 0 0 9 0 9 9 0 34 9 17 0 0 0 9 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _