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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HSD11B2 All Species: 9.09
Human Site: Y295 Identified Species: 18.18
UniProt: P80365 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.27
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P80365 NP_000187.3 405 44127 Y295 P Q E L L Q A Y G K D Y I E H
Chimpanzee Pan troglodytes XP_523393 405 44092 Y295 P Q E L L Q A Y G K D Y I E H
Rhesus Macaque Macaca mulatta XP_001088119 491 53541 Y381 P Q E L L Q A Y G K D Y I E H
Dog Lupus familis XP_853935 323 35433 E215 E L L Q A Y G E D Y I E H L H
Cat Felis silvestris
Mouse Mus musculus P51661 386 42168 K278 T N V N L W E K R K Q L L L A
Rat Rattus norvegicus P50233 400 43708 L291 L A N L P R E L L Q A Y G E D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001512268 333 36740 D225 M E D P R I W D Q R K Q R L L
Chicken Gallus gallus Q5ZJZ5 339 38218 I231 P Q G V M V S I V E P G N F I
Frog Xenopus laevis Q0IH28 323 35135 D215 E M S P Y D I D V T V V N P G
Zebra Danio Brachydanio rerio Q566S6 309 33329 A201 A S K H A M Q A Y Y D C L R A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9Y140 326 35725 D218 H A M Q A F A D S L R A E V A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001130780 400 43694 L291 L A N L P R E L L Q A Y G E D
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.7 81 70.1 N.A. 82.9 85.6 N.A. 58.2 25.6 21.4 22.7 N.A. 21.4 N.A. N.A. N.A.
Protein Similarity: 100 100 81.4 75.8 N.A. 88.8 90.6 N.A. 66.9 41.4 37.5 35.3 N.A. 35.5 N.A. N.A. N.A.
P-Site Identity: 100 100 100 6.6 N.A. 13.3 20 N.A. 0 13.3 0 6.6 N.A. 6.6 N.A. N.A. N.A.
P-Site Similarity: 100 100 100 6.6 N.A. 20 33.3 N.A. 20 40 0 20 N.A. 6.6 N.A. N.A. N.A.
Percent
Protein Identity: N.A. 85.6 N.A. N.A. N.A. N.A.
Protein Similarity: N.A. 90.8 N.A. N.A. N.A. N.A.
P-Site Identity: N.A. 20 N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. 33.3 N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 25 0 0 25 0 34 9 0 0 17 9 0 0 25 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % C
% Asp: 0 0 9 0 0 9 0 25 9 0 34 0 0 0 17 % D
% Glu: 17 9 25 0 0 0 25 9 0 9 0 9 9 42 0 % E
% Phe: 0 0 0 0 0 9 0 0 0 0 0 0 0 9 0 % F
% Gly: 0 0 9 0 0 0 9 0 25 0 0 9 17 0 9 % G
% His: 9 0 0 9 0 0 0 0 0 0 0 0 9 0 34 % H
% Ile: 0 0 0 0 0 9 9 9 0 0 9 0 25 0 9 % I
% Lys: 0 0 9 0 0 0 0 9 0 34 9 0 0 0 0 % K
% Leu: 17 9 9 42 34 0 0 17 17 9 0 9 17 25 9 % L
% Met: 9 9 9 0 9 9 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 9 17 9 0 0 0 0 0 0 0 0 17 0 0 % N
% Pro: 34 0 0 17 17 0 0 0 0 0 9 0 0 9 0 % P
% Gln: 0 34 0 17 0 25 9 0 9 17 9 9 0 0 0 % Q
% Arg: 0 0 0 0 9 17 0 0 9 9 9 0 9 9 0 % R
% Ser: 0 9 9 0 0 0 9 0 9 0 0 0 0 0 0 % S
% Thr: 9 0 0 0 0 0 0 0 0 9 0 0 0 0 0 % T
% Val: 0 0 9 9 0 9 0 0 17 0 9 9 0 9 0 % V
% Trp: 0 0 0 0 0 9 9 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 9 9 0 25 9 17 0 42 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _