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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HSD11B2
All Species:
11.52
Human Site:
Y299
Identified Species:
23.03
UniProt:
P80365
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P80365
NP_000187.3
405
44127
Y299
L
Q
A
Y
G
K
D
Y
I
E
H
L
H
G
Q
Chimpanzee
Pan troglodytes
XP_523393
405
44092
Y299
L
Q
A
Y
G
K
D
Y
I
E
H
L
H
G
Q
Rhesus Macaque
Macaca mulatta
XP_001088119
491
53541
Y385
L
Q
A
Y
G
K
D
Y
I
E
H
L
H
G
Q
Dog
Lupus familis
XP_853935
323
35433
E219
A
Y
G
E
D
Y
I
E
H
L
H
G
Q
F
L
Cat
Felis silvestris
Mouse
Mus musculus
P51661
386
42168
L282
L
W
E
K
R
K
Q
L
L
L
A
N
I
P
R
Rat
Rattus norvegicus
P50233
400
43708
Y295
P
R
E
L
L
Q
A
Y
G
E
D
Y
I
E
H
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001512268
333
36740
Q229
R
I
W
D
Q
R
K
Q
R
L
L
A
S
L
P
Chicken
Gallus gallus
Q5ZJZ5
339
38218
G235
M
V
S
I
V
E
P
G
N
F
I
A
V
T
N
Frog
Xenopus laevis
Q0IH28
323
35135
V219
Y
D
I
D
V
T
V
V
N
P
G
Y
I
K
T
Zebra Danio
Brachydanio rerio
Q566S6
309
33329
C205
A
M
Q
A
Y
Y
D
C
L
R
A
E
V
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9Y140
326
35725
A222
A
F
A
D
S
L
R
A
E
V
A
N
K
N
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001130780
400
43694
Y295
P
R
E
L
L
Q
A
Y
G
E
D
Y
I
E
H
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.7
81
70.1
N.A.
82.9
85.6
N.A.
58.2
25.6
21.4
22.7
N.A.
21.4
N.A.
N.A.
N.A.
Protein Similarity:
100
100
81.4
75.8
N.A.
88.8
90.6
N.A.
66.9
41.4
37.5
35.3
N.A.
35.5
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
13.3
13.3
N.A.
0
0
0
6.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
6.6
N.A.
26.6
26.6
N.A.
6.6
20
0
13.3
N.A.
6.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
85.6
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
90.8
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
13.3
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
26.6
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
25
0
34
9
0
0
17
9
0
0
25
17
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
9
0
0
0
0
0
0
0
% C
% Asp:
0
9
0
25
9
0
34
0
0
0
17
0
0
9
0
% D
% Glu:
0
0
25
9
0
9
0
9
9
42
0
9
0
17
0
% E
% Phe:
0
9
0
0
0
0
0
0
0
9
0
0
0
9
0
% F
% Gly:
0
0
9
0
25
0
0
9
17
0
9
9
0
25
0
% G
% His:
0
0
0
0
0
0
0
0
9
0
34
0
25
0
17
% H
% Ile:
0
9
9
9
0
0
9
0
25
0
9
0
34
0
9
% I
% Lys:
0
0
0
9
0
34
9
0
0
0
0
0
9
9
0
% K
% Leu:
34
0
0
17
17
9
0
9
17
25
9
25
0
9
9
% L
% Met:
9
9
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
17
0
0
17
0
9
9
% N
% Pro:
17
0
0
0
0
0
9
0
0
9
0
0
0
9
9
% P
% Gln:
0
25
9
0
9
17
9
9
0
0
0
0
9
0
25
% Q
% Arg:
9
17
0
0
9
9
9
0
9
9
0
0
0
0
9
% R
% Ser:
0
0
9
0
9
0
0
0
0
0
0
0
9
0
9
% S
% Thr:
0
0
0
0
0
9
0
0
0
0
0
0
0
9
9
% T
% Val:
0
9
0
0
17
0
9
9
0
9
0
0
17
0
0
% V
% Trp:
0
9
9
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
9
0
25
9
17
0
42
0
0
0
25
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _