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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SIM1 All Species: 19.7
Human Site: S377 Identified Species: 39.39
UniProt: P81133 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P81133 NP_005059.2 766 85515 S377 G A K S R L S S S K S K S R T
Chimpanzee Pan troglodytes A2T6X9 766 85495 S377 G A K S R L S S S K S K S R T
Rhesus Macaque Macaca mulatta XP_001086054 766 85453 S377 G A K S R L S S S K S K S R T
Dog Lupus familis XP_539058 766 85506 S377 G A K S R L S S S K S K S R T
Cat Felis silvestris
Mouse Mus musculus Q61045 765 85522 S376 K G A K S R L S S S K S K S R
Rat Rattus norvegicus O35800 825 92301 F387 S E D T S C L F D K L K K E P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506044 764 85619 S376 G S K A R L S S T K S K S R T
Chicken Gallus gallus Q9YIB9 811 90524 F387 W D D T N S L F E K L K Q E P
Frog Xenopus laevis Q9I8A9 805 90946 L388 E E N N S E C L F D K L K Q E
Zebra Danio Brachydanio rerio Q98SJ5 745 82716 S360 S F T Y N S P S N P V T E N R
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P05709 697 76457 T312 P Q D L I E K T L Y Q Y I H A
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_782984 820 91461 Q376 K S K S S K Y Q P Y Q V Q T P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 99 98.6 N.A. 96.6 25.2 N.A. 91.3 25.5 20.3 72.3 N.A. 41.9 N.A. N.A. 42.6
Protein Similarity: 100 99.7 99.2 99.4 N.A. 98.4 41.9 N.A. 96 43.1 38.6 81.5 N.A. 54.3 N.A. N.A. 55.9
P-Site Identity: 100 100 100 100 N.A. 13.3 13.3 N.A. 80 13.3 0 6.6 N.A. 0 N.A. N.A. 13.3
P-Site Similarity: 100 100 100 100 N.A. 13.3 20 N.A. 100 20 13.3 13.3 N.A. 6.6 N.A. N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 34 9 9 0 0 0 0 0 0 0 0 0 0 9 % A
% Cys: 0 0 0 0 0 9 9 0 0 0 0 0 0 0 0 % C
% Asp: 0 9 25 0 0 0 0 0 9 9 0 0 0 0 0 % D
% Glu: 9 17 0 0 0 17 0 0 9 0 0 0 9 17 9 % E
% Phe: 0 9 0 0 0 0 0 17 9 0 0 0 0 0 0 % F
% Gly: 42 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 0 0 0 0 9 0 0 0 0 0 0 0 9 0 0 % I
% Lys: 17 0 50 9 0 9 9 0 0 59 17 59 25 0 0 % K
% Leu: 0 0 0 9 0 42 25 9 9 0 17 9 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 9 9 17 0 0 0 9 0 0 0 0 9 0 % N
% Pro: 9 0 0 0 0 0 9 0 9 9 0 0 0 0 25 % P
% Gln: 0 9 0 0 0 0 0 9 0 0 17 0 17 9 0 % Q
% Arg: 0 0 0 0 42 9 0 0 0 0 0 0 0 42 17 % R
% Ser: 17 17 0 42 34 17 42 59 42 9 42 9 42 9 0 % S
% Thr: 0 0 9 17 0 0 0 9 9 0 0 9 0 9 42 % T
% Val: 0 0 0 0 0 0 0 0 0 0 9 9 0 0 0 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 9 0 0 9 0 0 17 0 9 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _