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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIM1
All Species:
23.94
Human Site:
Y447
Identified Species:
47.88
UniProt:
P81133
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P81133
NP_005059.2
766
85515
Y447
S
D
R
S
S
L
C
Y
G
F
A
L
D
H
S
Chimpanzee
Pan troglodytes
A2T6X9
766
85495
Y447
S
D
R
S
S
L
C
Y
G
F
A
L
D
H
S
Rhesus Macaque
Macaca mulatta
XP_001086054
766
85453
Y447
S
D
R
S
S
L
C
Y
G
F
A
L
D
H
S
Dog
Lupus familis
XP_539058
766
85506
Y447
S
D
R
S
S
L
C
Y
G
F
A
L
D
H
S
Cat
Felis silvestris
Mouse
Mus musculus
Q61045
765
85522
Y446
P
D
R
S
S
L
C
Y
G
F
A
L
D
H
S
Rat
Rattus norvegicus
O35800
825
92301
T457
S
P
L
P
A
S
E
T
P
K
P
L
R
S
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506044
764
85619
Y446
S
D
R
G
S
L
C
Y
S
F
A
L
E
H
P
Chicken
Gallus gallus
Q9YIB9
811
90524
T457
P
L
P
A
S
E
T
T
K
P
L
R
S
N
A
Frog
Xenopus laevis
Q9I8A9
805
90946
P458
P
A
P
E
M
P
K
P
L
R
S
N
V
D
P
Zebra Danio
Brachydanio rerio
Q98SJ5
745
82716
V430
E
G
I
E
S
S
C
V
Y
R
Q
F
S
D
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P05709
697
76457
E382
S
V
N
Y
V
L
S
E
R
E
V
K
D
L
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782984
820
91461
G446
Y
S
A
S
Y
A
A
G
Y
Q
H
N
V
Y
T
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
98.6
N.A.
96.6
25.2
N.A.
91.3
25.5
20.3
72.3
N.A.
41.9
N.A.
N.A.
42.6
Protein Similarity:
100
99.7
99.2
99.4
N.A.
98.4
41.9
N.A.
96
43.1
38.6
81.5
N.A.
54.3
N.A.
N.A.
55.9
P-Site Identity:
100
100
100
100
N.A.
93.3
20
N.A.
73.3
6.6
0
13.3
N.A.
20
N.A.
N.A.
6.6
P-Site Similarity:
100
100
100
100
N.A.
93.3
26.6
N.A.
80
26.6
6.6
13.3
N.A.
20
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
9
9
9
9
9
0
0
0
50
0
0
0
9
% A
% Cys:
0
0
0
0
0
0
59
0
0
0
0
0
0
0
0
% C
% Asp:
0
50
0
0
0
0
0
0
0
0
0
0
50
17
0
% D
% Glu:
9
0
0
17
0
9
9
9
0
9
0
0
9
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
50
0
9
0
0
0
% F
% Gly:
0
9
0
9
0
0
0
9
42
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
9
0
0
50
0
% H
% Ile:
0
0
9
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
9
0
9
9
0
9
0
0
0
% K
% Leu:
0
9
9
0
0
59
0
0
9
0
9
59
0
9
0
% L
% Met:
0
0
0
0
9
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
9
0
0
0
0
0
0
0
0
17
0
9
0
% N
% Pro:
25
9
17
9
0
9
0
9
9
9
9
0
0
0
25
% P
% Gln:
0
0
0
0
0
0
0
0
0
9
9
0
0
0
0
% Q
% Arg:
0
0
50
0
0
0
0
0
9
17
0
9
9
0
0
% R
% Ser:
59
9
0
50
67
17
9
0
9
0
9
0
17
9
50
% S
% Thr:
0
0
0
0
0
0
9
17
0
0
0
0
0
0
9
% T
% Val:
0
9
0
0
9
0
0
9
0
0
9
0
17
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
9
9
0
0
50
17
0
0
0
0
9
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _