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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
SIM1
All Species:
25.76
Human Site:
Y677
Identified Species:
51.52
UniProt:
P81133
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P81133
NP_005059.2
766
85515
Y677
S
L
I
L
A
K
D
Y
L
H
S
D
I
S
P
Chimpanzee
Pan troglodytes
A2T6X9
766
85495
Y677
S
L
I
L
A
K
D
Y
L
H
S
D
I
S
P
Rhesus Macaque
Macaca mulatta
XP_001086054
766
85453
Y677
S
L
I
L
A
K
D
Y
L
H
S
D
I
S
P
Dog
Lupus familis
XP_539058
766
85506
Y677
S
L
I
L
A
K
D
Y
L
H
A
D
M
S
P
Cat
Felis silvestris
Mouse
Mus musculus
Q61045
765
85522
Y676
S
L
I
L
A
K
D
Y
L
H
S
D
M
S
P
Rat
Rattus norvegicus
O35800
825
92301
L690
A
H
P
R
S
L
N
L
S
V
T
L
N
Q
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506044
764
85619
Y676
S
L
I
L
A
K
D
Y
L
H
S
D
M
S
P
Chicken
Gallus gallus
Q9YIB9
811
90524
E689
K
R
S
T
A
M
D
E
E
L
N
P
K
M
L
Frog
Xenopus laevis
Q9I8A9
805
90946
P706
R
K
M
E
S
D
G
P
L
F
Q
A
I
G
I
Zebra Danio
Brachydanio rerio
Q98SJ5
745
82716
S657
D
F
L
Q
N
E
L
S
S
S
Q
L
P
L
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P05709
697
76457
T609
Y
Y
Y
D
Y
D
A
T
V
D
V
A
T
S
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_782984
820
91461
Y711
S
R
H
T
S
T
D
Y
S
A
R
S
T
S
P
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
99
98.6
N.A.
96.6
25.2
N.A.
91.3
25.5
20.3
72.3
N.A.
41.9
N.A.
N.A.
42.6
Protein Similarity:
100
99.7
99.2
99.4
N.A.
98.4
41.9
N.A.
96
43.1
38.6
81.5
N.A.
54.3
N.A.
N.A.
55.9
P-Site Identity:
100
100
100
86.6
N.A.
93.3
0
N.A.
93.3
13.3
13.3
0
N.A.
6.6
N.A.
N.A.
33.3
P-Site Similarity:
100
100
100
100
N.A.
100
26.6
N.A.
100
20
26.6
13.3
N.A.
13.3
N.A.
N.A.
40
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
9
0
0
0
59
0
9
0
0
9
9
17
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
9
0
0
9
0
17
67
0
0
9
0
50
0
0
0
% D
% Glu:
0
0
0
9
0
9
0
9
9
0
0
0
0
0
0
% E
% Phe:
0
9
0
0
0
0
0
0
0
9
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
9
0
0
0
0
0
0
9
0
% G
% His:
0
9
9
0
0
0
0
0
0
50
0
0
0
0
0
% H
% Ile:
0
0
50
0
0
0
0
0
0
0
0
0
34
0
9
% I
% Lys:
9
9
0
0
0
50
0
0
0
0
0
0
9
0
0
% K
% Leu:
0
50
9
50
0
9
9
9
59
9
0
17
0
9
9
% L
% Met:
0
0
9
0
0
9
0
0
0
0
0
0
25
9
9
% M
% Asn:
0
0
0
0
9
0
9
0
0
0
9
0
9
0
0
% N
% Pro:
0
0
9
0
0
0
0
9
0
0
0
9
9
0
59
% P
% Gln:
0
0
0
9
0
0
0
0
0
0
17
0
0
9
0
% Q
% Arg:
9
17
0
9
0
0
0
0
0
0
9
0
0
0
9
% R
% Ser:
59
0
9
0
25
0
0
9
25
9
42
9
0
67
0
% S
% Thr:
0
0
0
17
0
9
0
9
0
0
9
0
17
0
9
% T
% Val:
0
0
0
0
0
0
0
0
9
9
9
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
9
9
0
9
0
0
59
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _