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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA4
All Species:
20.3
Human Site:
S125
Identified Species:
44.67
UniProt:
P83105
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P83105
NP_710159.1
476
50979
S125
S
D
R
R
T
Y
P
S
M
C
A
L
R
A
E
Chimpanzee
Pan troglodytes
XP_528115
476
51017
S125
S
D
R
R
T
Y
P
S
M
C
A
L
R
A
E
Rhesus Macaque
Macaca mulatta
XP_001092132
476
50970
S125
S
D
R
R
T
Y
P
S
L
C
A
L
R
T
E
Dog
Lupus familis
XP_532799
392
42176
E71
K
G
D
C
A
G
R
E
A
W
S
V
G
R
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9R118
480
51228
N128
S
D
A
K
T
Y
T
N
L
C
Q
L
R
A
A
Rat
Rattus norvegicus
NP_001100791
488
52174
S136
S
D
G
R
T
Y
P
S
L
C
A
L
R
K
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
N112
S
D
G
R
T
Y
D
N
I
C
Q
L
K
A
V
Frog
Xenopus laevis
NP_001088796
457
48812
S105
S
D
G
K
T
Y
S
S
L
C
R
L
Q
A
E
Zebra Danio
Brachydanio rerio
XP_001338173
458
49907
S107
S
D
G
R
T
Y
P
S
I
C
R
L
K
A
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
L87
A
I
I
Q
R
E
D
L
T
P
T
I
A
A
S
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
G95
L
P
W
Q
I
S
P
G
L
I
H
R
P
E
Q
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89
59.4
N.A.
53.3
65.7
N.A.
N.A.
50.8
49.3
52.7
N.A.
35.5
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
93.4
69.5
N.A.
68.9
77.6
N.A.
N.A.
66.8
68
69.3
N.A.
52.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
0
N.A.
53.3
80
N.A.
N.A.
53.3
60
73.3
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
13.3
N.A.
73.3
86.6
N.A.
N.A.
73.3
80
86.6
N.A.
26.6
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
10
0
0
0
10
0
37
0
10
64
10
% A
% Cys:
0
0
0
10
0
0
0
0
0
73
0
0
0
0
0
% C
% Asp:
0
73
10
0
0
0
19
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
10
0
10
0
0
0
0
0
10
55
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
37
0
0
10
0
10
0
0
0
0
10
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
10
0
0
0
0
% H
% Ile:
0
10
10
0
10
0
0
0
19
10
0
10
0
0
0
% I
% Lys:
10
0
0
19
0
0
0
0
0
0
0
0
19
10
0
% K
% Leu:
10
0
0
0
0
0
0
10
46
0
0
73
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
19
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
19
0
0
0
0
0
0
0
% N
% Pro:
0
10
0
0
0
0
55
0
0
10
0
0
10
0
0
% P
% Gln:
0
0
0
19
0
0
0
0
0
0
19
0
10
0
10
% Q
% Arg:
0
0
28
55
10
0
10
0
0
0
19
10
46
10
0
% R
% Ser:
73
0
0
0
0
10
10
55
0
0
10
0
0
0
10
% S
% Thr:
0
0
0
0
73
0
10
0
10
0
10
0
0
10
0
% T
% Val:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
10
% V
% Trp:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
73
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _