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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA4
All Species:
5.76
Human Site:
S159
Identified Species:
12.67
UniProt:
P83105
Number Species:
10
Phosphosite Substitution
Charge Score:
0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P83105
NP_710159.1
476
50979
S159
C
G
D
T
G
T
R
S
A
G
P
L
R
R
N
Chimpanzee
Pan troglodytes
XP_528115
476
51017
S159
C
G
D
T
G
T
R
S
A
G
P
L
R
R
N
Rhesus Macaque
Macaca mulatta
XP_001092132
476
50970
R159
C
G
D
T
G
S
R
R
A
G
T
L
R
R
N
Dog
Lupus familis
XP_532799
392
42176
E90
N
F
L
A
A
V
V
E
K
V
A
P
S
V
V
Cat
Felis silvestris
Mouse
Mus musculus
Q9R118
480
51228
D161
A
C
G
Q
G
Q
E
D
P
N
S
L
R
H
K
Rat
Rattus norvegicus
NP_001100791
488
52174
R170
C
G
D
S
G
T
T
R
A
G
R
L
R
T
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
Q145
A
C
E
S
G
H
L
Q
S
S
S
P
R
Y
K
Frog
Xenopus laevis
NP_001088796
457
48812
D138
D
C
Q
Q
G
Q
K
D
P
D
S
P
R
Y
K
Zebra Danio
Brachydanio rerio
XP_001338173
458
49907
N140
P
C
E
T
G
S
R
N
P
S
S
M
R
Y
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
I106
R
R
R
D
F
N
F
I
A
D
V
V
A
G
C
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
S136
S
V
E
A
S
D
S
S
S
K
P
S
N
G
Y
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89
59.4
N.A.
53.3
65.7
N.A.
N.A.
50.8
49.3
52.7
N.A.
35.5
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
93.4
69.5
N.A.
68.9
77.6
N.A.
N.A.
66.8
68
69.3
N.A.
52.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
80
0
N.A.
20
60
N.A.
N.A.
13.3
13.3
26.6
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
86.6
0
N.A.
20
66.6
N.A.
N.A.
33.3
20
53.3
N.A.
13.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
19
0
0
19
10
0
0
0
46
0
10
0
10
0
0
% A
% Cys:
37
37
0
0
0
0
0
0
0
0
0
0
0
0
10
% C
% Asp:
10
0
37
10
0
10
0
19
0
19
0
0
0
0
0
% D
% Glu:
0
0
28
0
0
0
10
10
0
0
0
0
0
0
0
% E
% Phe:
0
10
0
0
10
0
10
0
0
0
0
0
0
0
0
% F
% Gly:
0
37
10
0
73
0
0
0
0
37
0
0
0
19
0
% G
% His:
0
0
0
0
0
10
0
0
0
0
0
0
0
10
0
% H
% Ile:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
0
0
0
10
0
10
10
0
0
0
0
46
% K
% Leu:
0
0
10
0
0
0
10
0
0
0
0
46
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
10
0
0
0
0
10
0
10
0
10
0
0
10
0
28
% N
% Pro:
10
0
0
0
0
0
0
0
28
0
28
28
0
0
0
% P
% Gln:
0
0
10
19
0
19
0
10
0
0
0
0
0
0
0
% Q
% Arg:
10
10
10
0
0
0
37
19
0
0
10
0
73
28
0
% R
% Ser:
10
0
0
19
10
19
10
28
19
19
37
10
10
0
0
% S
% Thr:
0
0
0
37
0
28
10
0
0
0
10
0
0
10
0
% T
% Val:
0
10
0
0
0
10
10
0
0
10
10
10
0
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
28
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _