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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA4
All Species:
36.36
Human Site:
S268
Identified Species:
80
UniProt:
P83105
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P83105
NP_710159.1
476
50979
S268
P
V
L
M
L
G
R
S
S
D
L
R
A
G
E
Chimpanzee
Pan troglodytes
XP_528115
476
51017
S268
P
V
L
M
L
G
R
S
S
D
L
R
A
G
E
Rhesus Macaque
Macaca mulatta
XP_001092132
476
50970
S268
P
V
L
M
L
G
R
S
S
D
L
R
A
G
E
Dog
Lupus familis
XP_532799
392
42176
A188
G
R
S
S
D
L
Q
A
G
E
F
V
V
A
L
Cat
Felis silvestris
Mouse
Mus musculus
Q9R118
480
51228
S270
P
V
L
L
L
G
R
S
S
E
L
R
P
G
E
Rat
Rattus norvegicus
NP_001100791
488
52174
S279
P
V
L
L
L
G
R
S
S
D
L
R
A
G
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
S260
P
V
L
L
L
G
H
S
A
D
L
R
P
G
E
Frog
Xenopus laevis
NP_001088796
457
48812
S247
P
V
L
L
L
G
R
S
E
E
L
R
P
G
E
Zebra Danio
Brachydanio rerio
XP_001338173
458
49907
S249
P
V
L
L
L
G
R
S
S
D
L
R
P
G
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
S208
S
V
M
R
L
G
K
S
S
T
L
R
S
G
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
S253
P
T
A
K
L
G
F
S
S
K
L
R
P
G
D
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89
59.4
N.A.
53.3
65.7
N.A.
N.A.
50.8
49.3
52.7
N.A.
35.5
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
93.4
69.5
N.A.
68.9
77.6
N.A.
N.A.
66.8
68
69.3
N.A.
52.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
0
N.A.
80
93.3
N.A.
N.A.
73.3
73.3
86.6
N.A.
60
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
20
N.A.
93.3
100
N.A.
N.A.
86.6
86.6
93.3
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
0
0
0
10
10
0
0
0
37
10
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
10
0
0
0
0
55
0
0
0
0
10
% D
% Glu:
0
0
0
0
0
0
0
0
10
28
0
0
0
0
82
% E
% Phe:
0
0
0
0
0
0
10
0
0
0
10
0
0
0
0
% F
% Gly:
10
0
0
0
0
91
0
0
10
0
0
0
0
91
0
% G
% His:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
0
10
0
0
10
0
0
10
0
0
0
0
0
% K
% Leu:
0
0
73
46
91
10
0
0
0
0
91
0
0
0
10
% L
% Met:
0
0
10
28
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
82
0
0
0
0
0
0
0
0
0
0
0
46
0
0
% P
% Gln:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% Q
% Arg:
0
10
0
10
0
0
64
0
0
0
0
91
0
0
0
% R
% Ser:
10
0
10
10
0
0
0
91
73
0
0
0
10
0
0
% S
% Thr:
0
10
0
0
0
0
0
0
0
10
0
0
0
0
0
% T
% Val:
0
82
0
0
0
0
0
0
0
0
0
10
10
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _