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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA4
All Species:
10.3
Human Site:
S393
Identified Species:
22.67
UniProt:
P83105
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P83105
NP_710159.1
476
50979
S393
L
S
L
T
V
P
L
S
E
E
L
K
M
H
Y
Chimpanzee
Pan troglodytes
XP_528115
476
51017
S393
L
S
L
T
V
P
L
S
E
E
L
K
M
H
Y
Rhesus Macaque
Macaca mulatta
XP_001092132
476
50970
S393
L
P
L
T
M
P
L
S
K
E
L
K
I
H
Y
Dog
Lupus familis
XP_532799
392
42176
K312
M
N
L
L
Q
E
M
K
R
Q
D
P
D
F
P
Cat
Felis silvestris
Mouse
Mus musculus
Q9R118
480
51228
A395
M
S
L
T
S
S
K
A
K
E
L
K
D
R
H
Rat
Rattus norvegicus
NP_001100791
488
52174
L404
L
P
L
T
L
N
L
L
Q
E
M
K
R
Q
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
L385
T
P
A
L
V
E
E
L
K
H
N
N
A
D
F
Frog
Xenopus laevis
NP_001088796
457
48812
L372
M
S
L
S
Q
G
K
L
K
E
L
K
E
Q
V
Zebra Danio
Brachydanio rerio
XP_001338173
458
49907
I374
L
Q
L
S
A
A
L
I
R
E
L
R
E
K
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
T333
G
I
T
M
L
T
L
T
P
D
I
L
F
E
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
L378
N
N
L
I
V
A
Q
L
K
E
R
D
P
M
F
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89
59.4
N.A.
53.3
65.7
N.A.
N.A.
50.8
49.3
52.7
N.A.
35.5
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
93.4
69.5
N.A.
68.9
77.6
N.A.
N.A.
66.8
68
69.3
N.A.
52.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
73.3
6.6
N.A.
40
40
N.A.
N.A.
6.6
33.3
33.3
N.A.
6.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
33.3
N.A.
66.6
60
N.A.
N.A.
20
53.3
46.6
N.A.
33.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
40
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
10
19
0
10
0
0
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
0
0
10
10
10
19
10
10
% D
% Glu:
0
0
0
0
0
19
10
0
19
73
0
0
19
10
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
19
% F
% Gly:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
10
0
0
0
28
10
% H
% Ile:
0
10
0
10
0
0
0
10
0
0
10
0
10
0
0
% I
% Lys:
0
0
0
0
0
0
19
10
46
0
0
55
0
10
0
% K
% Leu:
46
0
82
19
19
0
55
37
0
0
55
10
0
0
10
% L
% Met:
28
0
0
10
10
0
10
0
0
0
10
0
19
10
0
% M
% Asn:
10
19
0
0
0
10
0
0
0
0
10
10
0
0
0
% N
% Pro:
0
28
0
0
0
28
0
0
10
0
0
10
10
0
10
% P
% Gln:
0
10
0
0
19
0
10
0
10
10
0
0
0
19
0
% Q
% Arg:
0
0
0
0
0
0
0
0
19
0
10
10
10
10
0
% R
% Ser:
0
37
0
19
10
10
0
28
0
0
0
0
0
0
0
% S
% Thr:
10
0
10
46
0
10
0
10
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
37
0
0
0
0
0
0
0
0
0
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
28
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _