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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA4
All Species:
34.55
Human Site:
Y314
Identified Species:
76
UniProt:
P83105
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P83105
NP_710159.1
476
50979
Y314
M
K
D
S
D
M
D
Y
V
Q
I
D
A
T
I
Chimpanzee
Pan troglodytes
XP_528115
476
51017
Y314
M
K
D
S
D
M
D
Y
V
Q
I
D
A
T
I
Rhesus Macaque
Macaca mulatta
XP_001092132
476
50970
Y314
M
K
D
S
D
I
D
Y
V
Q
I
D
A
A
I
Dog
Lupus familis
XP_532799
392
42176
A234
M
D
Y
I
Q
T
D
A
I
I
N
H
G
N
S
Cat
Felis silvestris
Mouse
Mus musculus
Q9R118
480
51228
Y316
L
R
N
S
D
M
D
Y
I
Q
T
D
A
I
I
Rat
Rattus norvegicus
NP_001100791
488
52174
Y325
L
K
D
S
D
I
D
Y
I
Q
T
D
A
I
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
Y306
L
R
D
S
D
M
D
Y
I
Q
T
D
A
I
I
Frog
Xenopus laevis
NP_001088796
457
48812
Y293
L
R
N
S
D
M
D
Y
I
Q
T
D
A
I
I
Zebra Danio
Brachydanio rerio
XP_001338173
458
49907
Y295
L
Q
N
S
D
M
E
Y
I
Q
T
D
A
I
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
Y254
L
R
N
R
D
I
N
Y
L
Q
T
D
A
A
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
Y299
L
G
G
K
H
R
E
Y
L
Q
T
D
C
S
I
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89
59.4
N.A.
53.3
65.7
N.A.
N.A.
50.8
49.3
52.7
N.A.
35.5
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
93.4
69.5
N.A.
68.9
77.6
N.A.
N.A.
66.8
68
69.3
N.A.
52.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
13.3
N.A.
60
66.6
N.A.
N.A.
66.6
60
53.3
N.A.
40
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
20
N.A.
86.6
86.6
N.A.
N.A.
86.6
86.6
86.6
N.A.
80
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
26.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
53.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
10
0
0
0
0
82
19
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
0
% C
% Asp:
0
10
46
0
82
0
73
0
0
0
0
91
0
0
0
% D
% Glu:
0
0
0
0
0
0
19
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
10
10
0
0
0
0
0
0
0
0
0
10
0
0
% G
% His:
0
0
0
0
10
0
0
0
0
0
0
10
0
0
0
% H
% Ile:
0
0
0
10
0
28
0
0
55
10
28
0
0
46
91
% I
% Lys:
0
37
0
10
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
64
0
0
0
0
0
0
0
19
0
0
0
0
0
0
% L
% Met:
37
0
0
0
0
55
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
37
0
0
0
10
0
0
0
10
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
10
0
0
10
0
0
0
0
91
0
0
0
0
0
% Q
% Arg:
0
37
0
10
0
10
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
0
0
73
0
0
0
0
0
0
0
0
0
10
10
% S
% Thr:
0
0
0
0
0
10
0
0
0
0
64
0
0
19
0
% T
% Val:
0
0
0
0
0
0
0
0
28
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
10
0
0
0
0
91
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _