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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA4
All Species:
9.09
Human Site:
Y400
Identified Species:
20
UniProt:
P83105
Number Species:
10
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P83105
NP_710159.1
476
50979
Y400
S
E
E
L
K
M
H
Y
P
D
F
P
D
V
S
Chimpanzee
Pan troglodytes
XP_528115
476
51017
Y400
S
E
E
L
K
M
H
Y
P
D
F
P
D
V
S
Rhesus Macaque
Macaca mulatta
XP_001092132
476
50970
Y400
S
K
E
L
K
I
H
Y
P
D
F
P
D
V
S
Dog
Lupus familis
XP_532799
392
42176
P319
K
R
Q
D
P
D
F
P
D
V
S
S
G
V
F
Cat
Felis silvestris
Mouse
Mus musculus
Q9R118
480
51228
H402
A
K
E
L
K
D
R
H
R
D
F
P
D
V
L
Rat
Rattus norvegicus
NP_001100791
488
52174
D411
L
Q
E
M
K
R
Q
D
P
D
F
P
D
V
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
F392
L
K
H
N
N
A
D
F
P
D
V
R
S
G
I
Frog
Xenopus laevis
NP_001088796
457
48812
V379
L
K
E
L
K
E
Q
V
K
D
F
P
E
N
T
Zebra Danio
Brachydanio rerio
XP_001338173
458
49907
E381
I
R
E
L
R
E
K
E
S
S
F
P
D
V
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
L340
T
P
D
I
L
F
E
L
K
S
R
S
Q
N
M
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
F385
L
K
E
R
D
P
M
F
P
D
V
E
R
G
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.3
89
59.4
N.A.
53.3
65.7
N.A.
N.A.
50.8
49.3
52.7
N.A.
35.5
N.A.
N.A.
N.A.
Protein Similarity:
100
99.5
93.4
69.5
N.A.
68.9
77.6
N.A.
N.A.
66.8
68
69.3
N.A.
52.9
N.A.
N.A.
N.A.
P-Site Identity:
100
100
86.6
6.6
N.A.
53.3
60
N.A.
N.A.
13.3
40
46.6
N.A.
0
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
13.3
N.A.
73.3
73.3
N.A.
N.A.
26.6
60
53.3
N.A.
20
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
29.8
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
20
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
33.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
0
0
0
10
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
10
10
10
19
10
10
10
73
0
0
55
0
0
% D
% Glu:
0
19
73
0
0
19
10
10
0
0
0
10
10
0
0
% E
% Phe:
0
0
0
0
0
10
10
19
0
0
64
0
0
0
10
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
10
19
0
% G
% His:
0
0
10
0
0
0
28
10
0
0
0
0
0
0
0
% H
% Ile:
10
0
0
10
0
10
0
0
0
0
0
0
0
0
10
% I
% Lys:
10
46
0
0
55
0
10
0
19
0
0
0
0
0
0
% K
% Leu:
37
0
0
55
10
0
0
10
0
0
0
0
0
0
10
% L
% Met:
0
0
0
10
0
19
10
0
0
0
0
0
0
0
10
% M
% Asn:
0
0
0
10
10
0
0
0
0
0
0
0
0
19
0
% N
% Pro:
0
10
0
0
10
10
0
10
55
0
0
64
0
0
0
% P
% Gln:
0
10
10
0
0
0
19
0
0
0
0
0
10
0
0
% Q
% Arg:
0
19
0
10
10
10
10
0
10
0
10
10
10
0
0
% R
% Ser:
28
0
0
0
0
0
0
0
10
19
10
19
10
0
46
% S
% Thr:
10
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% T
% Val:
0
0
0
0
0
0
0
10
0
10
19
0
0
64
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
28
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _