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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA3
All Species:
0
Human Site:
S375
Identified Species:
0
UniProt:
P83110
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.4
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P83110
NP_444272.1
453
48608
S375
L
V
D
E
L
K
A
S
N
P
D
F
P
E
V
Chimpanzee
Pan troglodytes
XP_508084
598
64926
R519
K
A
K
E
L
K
D
R
H
R
D
F
P
D
V
Rhesus Macaque
Macaca mulatta
XP_001103628
481
51453
R402
K
A
K
E
L
K
D
R
H
R
D
F
P
D
V
Dog
Lupus familis
XP_535044
364
39543
G295
D
F
P
D
V
L
S
G
A
Y
I
I
E
V
I
Cat
Felis silvestris
Mouse
Mus musculus
Q9D236
459
49131
A381
L
V
E
E
L
K
A
A
N
P
D
F
P
A
V
Rat
Rattus norvegicus
XP_341238
459
49239
A381
L
V
E
E
L
K
T
A
N
P
D
F
P
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
N388
L
V
E
E
L
K
H
N
N
A
D
F
P
D
V
Frog
Xenopus laevis
NP_001088796
457
48812
Q378
K
L
K
E
L
K
E
Q
V
K
D
F
P
E
N
Zebra Danio
Brachydanio rerio
NP_001003502
489
53108
H410
L
V
H
E
L
K
W
H
N
P
A
F
P
D
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
R343
I
L
F
E
L
K
S
R
S
Q
N
M
P
S
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
R381
I
V
A
Q
L
K
E
R
D
P
M
F
P
D
V
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
44.3
57.5
49.8
N.A.
91.7
91.2
N.A.
N.A.
77.4
56.8
63.3
N.A.
37
N.A.
N.A.
N.A.
Protein Similarity:
100
58.1
72.3
64.2
N.A.
95.4
94.9
N.A.
N.A.
85.1
71.9
75
N.A.
56.7
N.A.
N.A.
N.A.
P-Site Identity:
100
46.6
46.6
0
N.A.
80
73.3
N.A.
N.A.
66.6
46.6
60
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
60
60
26.6
N.A.
93.3
86.6
N.A.
N.A.
86.6
53.3
73.3
N.A.
60
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
46.6
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
73.3
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
19
10
0
0
0
19
19
10
10
10
0
0
19
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
10
10
0
0
19
0
10
0
64
0
0
46
0
% D
% Glu:
0
0
28
82
0
0
19
0
0
0
0
0
10
19
0
% E
% Phe:
0
10
10
0
0
0
0
0
0
0
0
82
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% G
% His:
0
0
10
0
0
0
10
10
19
0
0
0
0
0
0
% H
% Ile:
19
0
0
0
0
0
0
0
0
0
10
10
0
0
19
% I
% Lys:
28
0
28
0
0
91
0
0
0
10
0
0
0
0
0
% K
% Leu:
46
19
0
0
91
10
0
0
0
0
0
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
10
10
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
10
46
0
10
0
0
0
19
% N
% Pro:
0
0
10
0
0
0
0
0
0
46
0
0
91
0
0
% P
% Gln:
0
0
0
10
0
0
0
10
0
10
0
0
0
0
0
% Q
% Arg:
0
0
0
0
0
0
0
37
0
19
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
0
19
10
10
0
0
0
0
10
0
% S
% Thr:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% T
% Val:
0
55
0
0
10
0
0
0
10
0
0
0
0
10
64
% V
% Trp:
0
0
0
0
0
0
10
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _