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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HTRA3
All Species:
23.64
Human Site:
S419
Identified Species:
52
UniProt:
P83110
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P83110
NP_444272.1
453
48608
S419
N
G
R
P
L
V
D
S
S
E
L
Q
E
A
V
Chimpanzee
Pan troglodytes
XP_508084
598
64926
A563
N
G
Q
S
V
V
S
A
N
D
V
S
D
V
I
Rhesus Macaque
Macaca mulatta
XP_001103628
481
51453
A446
N
G
Q
S
V
V
S
A
N
D
V
S
D
V
I
Dog
Lupus familis
XP_535044
364
39543
V332
S
V
V
S
A
S
D
V
S
D
V
I
K
K
E
Cat
Felis silvestris
Mouse
Mus musculus
Q9D236
459
49131
S425
N
G
R
P
L
A
D
S
S
E
L
Q
E
A
V
Rat
Rattus norvegicus
XP_341238
459
49239
S425
N
G
R
P
L
V
D
S
S
E
L
Q
E
A
V
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
Chicken
Gallus gallus
XP_420813
466
50374
S432
N
G
R
P
L
M
T
S
S
D
L
Q
E
A
V
Frog
Xenopus laevis
NP_001088796
457
48812
S422
S
G
K
T
V
T
S
S
S
E
V
S
E
A
I
Zebra Danio
Brachydanio rerio
NP_001003502
489
53108
T454
N
G
H
P
L
M
N
T
G
E
L
Q
E
A
I
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q9VFJ3
422
45981
S388
N
K
K
E
I
K
N
S
S
D
V
Y
D
A
L
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q3E6S8
459
49256
I425
D
G
K
P
V
I
E
I
M
D
D
R
V
G
K
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
44.3
57.5
49.8
N.A.
91.7
91.2
N.A.
N.A.
77.4
56.8
63.3
N.A.
37
N.A.
N.A.
N.A.
Protein Similarity:
100
58.1
72.3
64.2
N.A.
95.4
94.9
N.A.
N.A.
85.1
71.9
75
N.A.
56.7
N.A.
N.A.
N.A.
P-Site Identity:
100
20
20
13.3
N.A.
93.3
100
N.A.
N.A.
80
40
60
N.A.
26.6
N.A.
N.A.
N.A.
P-Site Similarity:
100
73.3
73.3
40
N.A.
93.3
100
N.A.
N.A.
93.3
73.3
86.6
N.A.
73.3
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
31.3
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
48.8
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
13.3
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
60
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
10
10
0
19
0
0
0
0
0
64
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
10
0
0
0
0
0
37
0
0
55
10
0
28
0
0
% D
% Glu:
0
0
0
10
0
0
10
0
0
46
0
0
55
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
82
0
0
0
0
0
0
10
0
0
0
0
10
0
% G
% His:
0
0
10
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
10
10
0
10
0
0
0
10
0
0
37
% I
% Lys:
0
10
28
0
0
10
0
0
0
0
0
0
10
10
10
% K
% Leu:
0
0
0
0
46
0
0
0
0
0
46
0
0
0
10
% L
% Met:
0
0
0
0
0
19
0
0
10
0
0
0
0
0
0
% M
% Asn:
73
0
0
0
0
0
19
0
19
0
0
0
0
0
0
% N
% Pro:
0
0
0
55
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
19
0
0
0
0
0
0
0
0
46
0
0
0
% Q
% Arg:
0
0
37
0
0
0
0
0
0
0
0
10
0
0
0
% R
% Ser:
19
0
0
28
0
10
28
55
64
0
0
28
0
0
0
% S
% Thr:
0
0
0
10
0
10
10
10
0
0
0
0
0
0
0
% T
% Val:
0
10
10
0
37
37
0
10
0
0
46
0
10
19
37
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _