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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COG7 All Species: 13.03
Human Site: S245 Identified Species: 26.06
UniProt: P83436 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P83436 NP_705831.1 770 86344 S245 E L C Q S D L S L D R Q L T G
Chimpanzee Pan troglodytes XP_510875 770 86371 S245 E L C Q S D L S L D R Q L T G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536935 867 97126 P342 E L C Q S D L P L D R Q L T G
Cat Felis silvestris
Mouse Mus musculus Q3UM29 770 86054 P245 E L C Q S D L P L D R Q L T G
Rat Rattus norvegicus Q3T1G7 770 86193 P245 E L C Q R D L P L D R Q L T G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510180 777 87288 T252 E L C Q S D L T L D R Q L T E
Chicken Gallus gallus XP_001234080 769 86630 S244 D L C Q S D L S L N R Q L T E
Frog Xenopus laevis NP_001085832 768 86803 P244 E L C Q S D M P L D R Q L T E
Zebra Danio Brachydanio rerio NP_001070861 767 86211 P244 S I C Q S D A P L K Q Q L S E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VAD6 742 84057 Q246 W K Q T L E L Q G T E S Q P Q
Honey Bee Apis mellifera XP_394713 733 83501 N244 I E L A Q D E N V S Y W L H T
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203886 767 86354 L239 R C Q S L E V L K N R L E A L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 82.8 N.A. 92.4 91.4 N.A. 79.4 78.6 75.4 70.5 N.A. 28 36.7 N.A. 44.5
Protein Similarity: 100 99.8 N.A. 86.1 N.A. 95.8 95.1 N.A. 87.1 90.6 88.5 84.8 N.A. 48.1 56.8 N.A. 62
P-Site Identity: 100 100 N.A. 93.3 N.A. 93.3 86.6 N.A. 86.6 80 80 46.6 N.A. 6.6 13.3 N.A. 6.6
P-Site Similarity: 100 100 N.A. 93.3 N.A. 93.3 86.6 N.A. 93.3 93.3 86.6 66.6 N.A. 13.3 26.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 9 0 0 9 0 0 0 0 0 0 9 0 % A
% Cys: 0 9 75 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 9 0 0 0 0 84 0 0 0 59 0 0 0 0 0 % D
% Glu: 59 9 0 0 0 17 9 0 0 0 9 0 9 0 34 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 9 0 0 0 0 0 42 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 0 % H
% Ile: 9 9 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 9 0 0 0 0 0 0 9 9 0 0 0 0 0 % K
% Leu: 0 67 9 0 17 0 67 9 75 0 0 9 84 0 9 % L
% Met: 0 0 0 0 0 0 9 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 9 0 17 0 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 42 0 0 0 0 0 9 0 % P
% Gln: 0 0 17 75 9 0 0 9 0 0 9 75 9 0 9 % Q
% Arg: 9 0 0 0 9 0 0 0 0 0 75 0 0 0 0 % R
% Ser: 9 0 0 9 67 0 0 25 0 9 0 9 0 9 0 % S
% Thr: 0 0 0 9 0 0 0 9 0 9 0 0 0 67 9 % T
% Val: 0 0 0 0 0 0 9 0 9 0 0 0 0 0 0 % V
% Trp: 9 0 0 0 0 0 0 0 0 0 0 9 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _