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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: COG7 All Species: 22.73
Human Site: S299 Identified Species: 45.45
UniProt: P83436 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P83436 NP_705831.1 770 86344 S299 P S L P S C L S N G V E R A G
Chimpanzee Pan troglodytes XP_510875 770 86371 S299 P S L P S C L S N G V E R A G
Rhesus Macaque Macaca mulatta
Dog Lupus familis XP_536935 867 97126 S396 P T L P D C L S S G V E R A G
Cat Felis silvestris
Mouse Mus musculus Q3UM29 770 86054 S299 P S L P M C L S A A V E R A G
Rat Rattus norvegicus Q3T1G7 770 86193 S299 P S L P M C L S E A V E R A G
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510180 777 87288 A306 P S L P V C L A T G L E R V G
Chicken Gallus gallus XP_001234080 769 86630 S298 P S I P V C L S T A M E R T G
Frog Xenopus laevis NP_001085832 768 86803 S298 P S I P V C L S T A M E R A S
Zebra Danio Brachydanio rerio NP_001070861 767 86211 A298 P S I P D C I A E T L K R C S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q9VAD6 742 84057 L298 I A E L L P A L Q P T R D A H
Honey Bee Apis mellifera XP_394713 733 83501 E296 S L D P G I P E C I E S F L K
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001203886 767 86354 L292 K C H K S S L L L Q W Q Q L Q
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.6 N.A. 82.8 N.A. 92.4 91.4 N.A. 79.4 78.6 75.4 70.5 N.A. 28 36.7 N.A. 44.5
Protein Similarity: 100 99.8 N.A. 86.1 N.A. 95.8 95.1 N.A. 87.1 90.6 88.5 84.8 N.A. 48.1 56.8 N.A. 62
P-Site Identity: 100 100 N.A. 80 N.A. 80 80 N.A. 66.6 60 60 33.3 N.A. 6.6 6.6 N.A. 13.3
P-Site Similarity: 100 100 N.A. 93.3 N.A. 80 80 N.A. 80 73.3 73.3 66.6 N.A. 13.3 6.6 N.A. 26.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 9 0 0 0 0 9 17 9 34 0 0 0 59 0 % A
% Cys: 0 9 0 0 0 75 0 0 9 0 0 0 0 9 0 % C
% Asp: 0 0 9 0 17 0 0 0 0 0 0 0 9 0 0 % D
% Glu: 0 0 9 0 0 0 0 9 17 0 9 67 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 9 0 0 % F
% Gly: 0 0 0 0 9 0 0 0 0 34 0 0 0 0 59 % G
% His: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 9 % H
% Ile: 9 0 25 0 0 9 9 0 0 9 0 0 0 0 0 % I
% Lys: 9 0 0 9 0 0 0 0 0 0 0 9 0 0 9 % K
% Leu: 0 9 50 9 9 0 75 17 9 0 17 0 0 17 0 % L
% Met: 0 0 0 0 17 0 0 0 0 0 17 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 17 0 0 0 0 0 0 % N
% Pro: 75 0 0 84 0 9 9 0 0 9 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 9 9 0 9 9 0 9 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 9 75 0 0 % R
% Ser: 9 67 0 0 25 9 0 59 9 0 0 9 0 0 17 % S
% Thr: 0 9 0 0 0 0 0 0 25 9 9 0 0 9 0 % T
% Val: 0 0 0 0 25 0 0 0 0 0 42 0 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _