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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HPCA All Species: 31.52
Human Site: T158 Identified Species: 53.33
UniProt: P84074 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P84074 NP_002134.2 193 22427 T158 K I F R Q M D T N N D G K L S
Chimpanzee Pan troglodytes XP_001155509 344 38260 T309 K I F R Q M D T N N D G K L S
Rhesus Macaque Macaca mulatta XP_001098851 408 45214 T373 K I F R Q M D T N N D G K L S
Dog Lupus familis XP_852217 329 37131 T294 K I F R Q M D T N N D G K L S
Cat Felis silvestris
Mouse Mus musculus Q8BGZ1 191 22197 K156 Q R V D K I F K K M D Q D K D
Rat Rattus norvegicus P84076 193 22409 T158 K I F R Q M D T N N D G K L S
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus P42324 193 22251 T158 K I F R Q M D T N N D G K L S
Frog Xenopus laevis Q6DCM9 193 22267 T158 K I F K Q M D T N N D G K L S
Zebra Danio Brachydanio rerio A9JTH1 193 22206 T158 K I F R Q M D T N R D G K L S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P42325 190 21875 M156 T D K I F R Q M D R N K D G K
Honey Bee Apis mellifera XP_392256 192 21952 K158 K I F R Q M D K N K D G K L S
Nematode Worm Caenorhab. elegans P36608 191 22003 D157 D R I F R M M D K N N D A Q L
Sea Urchin Strong. purpuratus XP_783112 194 22350 E158 K I F R Q M D E N L D G K L S
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae Q06389 190 21992 M156 V K K I F K L M D K N E D G Y
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 56 47.2 54.7 N.A. 66.8 100 N.A. N.A. 93.2 92.2 87 N.A. 83.4 83.9 56.9 85.5
Protein Similarity: 100 56 47.2 56.8 N.A. 82.3 100 N.A. N.A. 96.8 96.3 94.8 N.A. 91.1 92.7 73 91.7
P-Site Identity: 100 100 100 100 N.A. 6.6 100 N.A. N.A. 100 93.3 93.3 N.A. 0 86.6 13.3 86.6
P-Site Similarity: 100 100 100 100 N.A. 26.6 100 N.A. N.A. 100 100 93.3 N.A. 13.3 86.6 26.6 86.6
Percent
Protein Identity: N.A. N.A. N.A. N.A. 48.7 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 68.3 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 0 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 0 0 0 8 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 8 8 0 8 0 0 72 8 15 0 79 8 22 0 8 % D
% Glu: 0 0 0 0 0 0 0 8 0 0 0 8 0 0 0 % E
% Phe: 0 0 72 8 15 0 8 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 72 0 15 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 72 8 15 0 8 0 0 0 0 0 0 0 0 0 % I
% Lys: 72 8 15 8 8 8 0 15 15 15 0 8 72 8 8 % K
% Leu: 0 0 0 0 0 0 8 0 0 8 0 0 0 72 8 % L
% Met: 0 0 0 0 0 79 8 15 0 8 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 72 58 22 0 0 0 0 % N
% Pro: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 8 0 0 0 72 0 8 0 0 0 0 8 0 8 0 % Q
% Arg: 0 15 0 65 8 8 0 0 0 15 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 72 % S
% Thr: 8 0 0 0 0 0 0 58 0 0 0 0 0 0 0 % T
% Val: 8 0 8 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _