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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CYCS All Species: 41.52
Human Site: Y49 Identified Species: 91.33
UniProt: P99999 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens P99999 NP_061820.1 105 11749 Y49 G Q A P G Y S Y T A A N K N K
Chimpanzee Pan troglodytes P99998 105 11730 Y49 G Q A P G Y S Y T A A N K N K
Rhesus Macaque Macaca mulatta XP_001095344 105 11718 Y49 G Q A P G Y S Y T A A N K N K
Dog Lupus familis XP_532493 105 11614 Y49 G Q A P G F S Y T D A N K N K
Cat Felis silvestris
Mouse Mus musculus P00015 105 11695 Y49 G Q A P G F S Y T D A N K N K
Rat Rattus norvegicus P62898 105 11587 Y49 G Q A A G F S Y T D A N K N K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508357 105 11625 Y49 G Q A P G F S Y T D A N K S K
Chicken Gallus gallus P67881 105 11692 Y49 G Q A E G F S Y T D A N K N K
Frog Xenopus laevis Q6DKE1 105 11677 Y49 G Q A E G F S Y T D A N K N K
Zebra Danio Brachydanio rerio Q6IQM2 104 11438 Y49 G Q A E G F S Y T D A N K S K
Tiger Blowfish Takifugu rubipres Q1KKS2 105 11557 Y50 G Q A E G F S Y T D A N K S K
Fruit Fly Dros. melanogaster
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 100 99 89.5 N.A. 82.8 91.4 N.A. 86.6 87.6 84.7 83.8 80 N.A. N.A. N.A. N.A.
Protein Similarity: 100 100 99 93.3 N.A. 89.5 94.2 N.A. 93.3 92.3 91.4 90.4 88.5 N.A. N.A. N.A. N.A.
P-Site Identity: 100 100 100 86.6 N.A. 86.6 80 N.A. 80 80 80 73.3 73.3 N.A. N.A. N.A. N.A.
P-Site Similarity: 100 100 100 93.3 N.A. 93.3 86.6 N.A. 93.3 86.6 86.6 86.6 86.6 N.A. N.A. N.A. N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 100 10 0 0 0 0 0 28 100 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 73 0 0 0 0 0 % D
% Glu: 0 0 0 37 0 0 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 0 0 73 0 0 0 0 0 0 0 0 0 % F
% Gly: 100 0 0 0 100 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 0 0 0 0 0 0 100 0 100 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 100 0 73 0 % N
% Pro: 0 0 0 55 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 100 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % R
% Ser: 0 0 0 0 0 0 100 0 0 0 0 0 0 28 0 % S
% Thr: 0 0 0 0 0 0 0 0 100 0 0 0 0 0 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 28 0 100 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _