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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC25A3 All Species: 48.48
Human Site: S353 Identified Species: 71.11
UniProt: Q00325 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00325 NP_002626.1 362 40095 S353 P P P E M P E S L K K K L G L
Chimpanzee Pan troglodytes XP_509289 315 34683 F307 L V L K R L G F K G R M M F F
Rhesus Macaque Macaca mulatta XP_001083690 362 40156 S353 P P P E M P E S L K K K L G L
Dog Lupus familis XP_866402 362 39917 S353 P P P E M P E S L K K K L G L
Cat Felis silvestris
Mouse Mus musculus Q8VEM8 357 39614 S348 P P P E M P E S L K K K L G L
Rat Rattus norvegicus P16036 356 39427 S347 P P P E M P E S L K K K L G L
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506076 369 41102 S360 P P P E M P E S L K K K L G L
Chicken Gallus gallus NP_001006236 335 37403 L327 P P E M P E S L K K K L G L T
Frog Xenopus laevis NP_001080195 359 39888 S350 P P P E M P E S L K K K L G L
Zebra Danio Brachydanio rerio NP_998887 356 39288 S347 P P P E M P E S L K K K L G L
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_611468 374 40535 S363 P P P E M P E S L K K K L G V
Honey Bee Apis mellifera XP_396960 354 39111 S346 P P P E M P E S L K K K Y G L
Nematode Worm Caenorhab. elegans P40614 340 36655 S331 P P P E M P A S L K A K L A A
Sea Urchin Strong. purpuratus XP_783048 356 39100 P342 V F F R M P R P P P P E M P K
Poplar Tree Populus trichocarpa
Maize Zea mays NP_001140930 356 39513 S347 P P P E M P E S L K K K L G L
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P40035 300 33510 A292 L I Y D S F K A Y V G L P T T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 83.4 98.3 95.3 N.A. 88.6 88.1 N.A. 81.3 79 82.8 79.5 N.A. 67.3 67.1 65.4 69.3
Protein Similarity: 100 85.9 99.4 96.1 N.A. 93.9 93.6 N.A. 87.2 84.2 90 87 N.A. 79.9 79.5 75.6 81.2
P-Site Identity: 100 0 100 100 N.A. 100 100 N.A. 100 26.6 100 100 N.A. 93.3 93.3 73.3 13.3
P-Site Similarity: 100 20 100 100 N.A. 100 100 N.A. 100 26.6 100 100 N.A. 100 93.3 73.3 26.6
Percent
Protein Identity: N.A. 88.6 N.A. N.A. 41.9 N.A.
Protein Similarity: N.A. 93.9 N.A. N.A. 56.9 N.A.
P-Site Identity: N.A. 100 N.A. N.A. 0 N.A.
P-Site Similarity: N.A. 100 N.A. N.A. 20 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 7 7 0 0 7 0 0 7 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 7 0 0 0 0 0 0 0 0 0 0 0 % D
% Glu: 0 0 7 75 0 7 69 0 0 0 0 7 0 0 0 % E
% Phe: 0 7 7 0 0 7 0 7 0 0 0 0 0 7 7 % F
% Gly: 0 0 0 0 0 0 7 0 0 7 7 0 7 69 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 7 0 0 7 0 13 82 75 75 0 0 7 % K
% Leu: 13 0 7 0 0 7 0 7 75 0 0 13 69 7 63 % L
% Met: 0 0 0 7 82 0 0 0 0 0 0 7 13 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % N
% Pro: 82 82 75 0 7 82 0 7 7 7 7 0 7 7 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 0 7 7 0 7 0 0 0 7 0 0 0 0 % R
% Ser: 0 0 0 0 7 0 7 75 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 13 % T
% Val: 7 7 0 0 0 0 0 0 0 7 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 0 0 0 0 7 0 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _