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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK6 All Species: 34.55
Human Site: S155 Identified Species: 54.29
UniProt: Q00534 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.14
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00534 NP_001138778.1 326 36938 S155 P Q N I L V T S S G Q I K L A
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001116412 303 33725 S150 P E N I L V T S G G T V K L A
Dog Lupus familis XP_852360 326 36788 S155 P Q N I L V T S S G Q I K L A
Cat Felis silvestris
Mouse Mus musculus Q64261 326 37010 S155 P Q N I L V T S S G Q I K L A
Rat Rattus norvegicus P35426 303 33780 S150 P E N I L V T S N G T V K L A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511310 202 22667 T53 Y S F Q M A L T S V V V T L W
Chicken Gallus gallus P13863 303 34670 G140 N L L I D D K G V I K L A D F
Frog Xenopus laevis Q91727 319 35666 S150 P E N I L V T S G G Q V K L A
Zebra Danio Brachydanio rerio NP_001137525 302 33962 S152 P Q N I L V T S G G Q I K L A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477196 317 36383 S167 P Q N L L V S S Q G H L K I A
Honey Bee Apis mellifera XP_391955 457 50351 R307 P Q N L L V T R E G R I K I A
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999689 373 42086 S156 P Q N I L V A S D K K L K L T
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816 N140 L L I D R R T N A L K L A D F
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 N140 L L I D R R T N S L K L A D F
Baker's Yeast Sacchar. cerevisiae P00546 298 34043 K146 P Q N L L I N K D G N L K L G
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 65.6 96.6 N.A. 96.3 65 N.A. 56.1 43.5 65.3 76 N.A. 42.6 37.6 N.A. 50.6
Protein Similarity: 100 N.A. 76 97.5 N.A. 98.1 76 N.A. 58.5 61.9 77.9 83.1 N.A. 63.7 50.5 N.A. 63
P-Site Identity: 100 N.A. 73.3 100 N.A. 100 73.3 N.A. 13.3 6.6 80 93.3 N.A. 60 66.6 N.A. 60
P-Site Similarity: 100 N.A. 86.6 100 N.A. 100 93.3 N.A. 33.3 20 93.3 93.3 N.A. 86.6 86.6 N.A. 73.3
Percent
Protein Identity: N.A. 44.4 N.A. 44.7 40.1 N.A.
Protein Similarity: N.A. 62.2 N.A. 62.2 59.8 N.A.
P-Site Identity: N.A. 6.6 N.A. 13.3 46.6 N.A.
P-Site Similarity: N.A. 33.3 N.A. 33.3 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 7 7 0 7 0 0 0 20 0 60 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 14 7 7 0 0 14 0 0 0 0 20 0 % D
% Glu: 0 20 0 0 0 0 0 0 7 0 0 0 0 0 0 % E
% Phe: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 20 % F
% Gly: 0 0 0 0 0 0 0 7 20 67 0 0 0 0 7 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % H
% Ile: 0 0 14 60 0 7 0 0 0 7 0 34 0 14 0 % I
% Lys: 0 0 0 0 0 0 7 7 0 7 27 0 74 0 0 % K
% Leu: 14 20 7 20 74 0 7 0 0 14 0 40 0 67 0 % L
% Met: 0 0 0 0 7 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 74 0 0 0 7 14 7 0 7 0 0 0 0 % N
% Pro: 74 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % P
% Gln: 0 54 0 7 0 0 0 0 7 0 34 0 0 0 0 % Q
% Arg: 0 0 0 0 14 14 0 7 0 0 7 0 0 0 0 % R
% Ser: 0 7 0 0 0 0 7 60 34 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 67 7 0 0 14 0 7 0 7 % T
% Val: 0 0 0 0 0 67 0 0 7 7 7 27 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % W
% Tyr: 7 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _