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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK6 All Species: 11.52
Human Site: S256 Identified Species: 18.1
UniProt: Q00534 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00534 NP_001138778.1 326 36938 S256 L P R Q A F H S K S A Q P I E
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001116412 303 33725 P234 F D L I G L P P E D D W P R D
Dog Lupus familis XP_852360 326 36788 S256 L P R Q A F H S K S P Q P I E
Cat Felis silvestris
Mouse Mus musculus Q64261 326 37010 S256 L P R Q A F H S K S A Q P I E
Rat Rattus norvegicus P35426 303 33780 P234 F D L I G L P P E D D W P R E
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511310 202 22667 K133 P R Q A F H A K P P Q P I E K
Chicken Gallus gallus P13863 303 34670 N225 R A L G T P N N D V W P D V E
Frog Xenopus laevis Q91727 319 35666 S234 F D I I G L P S E E E W P V D
Zebra Danio Brachydanio rerio NP_001137525 302 33962 V232 Q L G K I F D V V G V P S P E
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477196 317 36383 T247 L D R I F E L T G R P T E Q Q
Honey Bee Apis mellifera XP_391955 457 50351 G388 D R I F Q I I G T P S Q G E W
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999689 373 42086 Q256 L P W S S F R Q T G Q R S F L
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816 E225 R I L G T P N E Q S W P G V S
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 E225 R I M G T P Y E D T W R G V T
Baker's Yeast Sacchar. cerevisiae P00546 298 34043 G229 F K I F R V L G T P N E A I W
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 65.6 96.6 N.A. 96.3 65 N.A. 56.1 43.5 65.3 76 N.A. 42.6 37.6 N.A. 50.6
Protein Similarity: 100 N.A. 76 97.5 N.A. 98.1 76 N.A. 58.5 61.9 77.9 83.1 N.A. 63.7 50.5 N.A. 63
P-Site Identity: 100 N.A. 6.6 93.3 N.A. 100 13.3 N.A. 0 6.6 13.3 13.3 N.A. 13.3 6.6 N.A. 20
P-Site Similarity: 100 N.A. 20 93.3 N.A. 100 20 N.A. 13.3 26.6 33.3 20 N.A. 26.6 13.3 N.A. 33.3
Percent
Protein Identity: N.A. 44.4 N.A. 44.7 40.1 N.A.
Protein Similarity: N.A. 62.2 N.A. 62.2 59.8 N.A.
P-Site Identity: N.A. 6.6 N.A. 0 6.6 N.A.
P-Site Similarity: N.A. 26.6 N.A. 26.6 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 7 0 7 20 0 7 0 0 0 14 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 7 27 0 0 0 0 7 0 14 14 14 0 7 0 14 % D
% Glu: 0 0 0 0 0 7 0 14 20 7 7 7 7 14 40 % E
% Phe: 27 0 0 14 14 34 0 0 0 0 0 0 0 7 0 % F
% Gly: 0 0 7 20 20 0 0 14 7 14 0 0 20 0 0 % G
% His: 0 0 0 0 0 7 20 0 0 0 0 0 0 0 0 % H
% Ile: 0 14 20 27 7 7 7 0 0 0 0 0 7 27 0 % I
% Lys: 0 7 0 7 0 0 0 7 20 0 0 0 0 0 7 % K
% Leu: 34 7 27 0 0 20 14 0 0 0 0 0 0 0 7 % L
% Met: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 14 7 0 0 7 0 0 0 0 % N
% Pro: 7 27 0 0 0 20 20 14 7 20 14 27 40 7 0 % P
% Gln: 7 0 7 20 7 0 0 7 7 0 14 27 0 7 7 % Q
% Arg: 20 14 27 0 7 0 7 0 0 7 0 14 0 14 0 % R
% Ser: 0 0 0 7 7 0 0 27 0 27 7 0 14 0 7 % S
% Thr: 0 0 0 0 20 0 0 7 20 7 0 7 0 0 7 % T
% Val: 0 0 0 0 0 7 0 7 7 7 7 0 0 27 0 % V
% Trp: 0 0 7 0 0 0 0 0 0 0 20 20 0 0 14 % W
% Tyr: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _