KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
9.7
Human Site:
S312
Identified Species:
15.24
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
S312
R
C
K
E
N
L
D
S
H
L
P
P
S
Q
N
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
L290
R
I
S
A
F
R
A
L
Q
H
S
Y
L
H
K
Dog
Lupus familis
XP_852360
326
36788
S312
R
C
K
E
N
L
D
S
H
L
P
P
S
Q
N
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
S312
R
Y
K
D
N
L
N
S
H
L
P
S
N
Q
S
Rat
Rattus norvegicus
P35426
303
33780
L290
R
I
S
A
F
R
A
L
Q
H
S
Y
L
H
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
R189
G
K
E
T
L
D
S
R
I
C
P
G
Q
T
T
Chicken
Gallus gallus
P13863
303
34670
A281
K
R
I
S
G
K
M
A
L
N
H
P
Y
F
D
Frog
Xenopus laevis
Q91727
319
35666
L290
R
I
S
A
S
D
A
L
L
H
P
F
F
A
D
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
Q288
T
S
K
S
L
Y
A
Q
P
F
P
S
K
K
P
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
A303
D
L
H
L
R
P
S
A
L
A
C
L
E
H
D
Honey Bee
Apis mellifera
XP_391955
457
50351
A444
P
H
R
R
L
T
A
A
Q
A
L
R
H
R
Y
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
D312
E
D
D
E
E
D
D
D
T
E
V
E
D
D
D
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
A281
K
R
I
T
A
R
Q
A
L
E
H
E
Y
F
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
A281
K
R
I
N
A
R
A
A
L
E
H
E
Y
F
K
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
S285
Y
D
P
I
N
R
I
S
A
R
R
A
A
I
H
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
6.6
100
N.A.
60
6.6
N.A.
6.6
6.6
13.3
13.3
N.A.
0
0
N.A.
13.3
P-Site Similarity:
100
N.A.
6.6
100
N.A.
86.6
6.6
N.A.
13.3
26.6
26.6
20
N.A.
13.3
20
N.A.
20
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
0
N.A.
0
13.3
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
20
14
0
40
34
7
14
0
7
7
7
0
% A
% Cys:
0
14
0
0
0
0
0
0
0
7
7
0
0
0
0
% C
% Asp:
7
14
7
7
0
20
20
7
0
0
0
0
7
7
27
% D
% Glu:
7
0
7
20
7
0
0
0
0
20
0
20
7
0
0
% E
% Phe:
0
0
0
0
14
0
0
0
0
7
0
7
7
20
0
% F
% Gly:
7
0
0
0
7
0
0
0
0
0
0
7
0
0
0
% G
% His:
0
7
7
0
0
0
0
0
20
20
20
0
7
20
7
% H
% Ile:
0
20
20
7
0
0
7
0
7
0
0
0
0
7
0
% I
% Lys:
20
7
27
0
0
7
0
0
0
0
0
0
7
7
27
% K
% Leu:
0
7
0
7
20
20
0
20
34
20
7
7
14
0
0
% L
% Met:
0
0
0
0
0
0
7
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
7
27
0
7
0
0
7
0
0
7
0
14
% N
% Pro:
7
0
7
0
0
7
0
0
7
0
40
20
0
0
7
% P
% Gln:
0
0
0
0
0
0
7
7
20
0
0
0
7
20
0
% Q
% Arg:
40
20
7
7
7
34
0
7
0
7
7
7
0
7
0
% R
% Ser:
0
7
20
14
7
0
14
27
0
0
14
14
14
0
7
% S
% Thr:
7
0
0
14
0
7
0
0
7
0
0
0
0
7
7
% T
% Val:
0
0
0
0
0
0
0
0
0
0
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
7
7
0
0
0
7
0
0
0
0
0
14
20
0
7
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _