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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK6 All Species: 18.79
Human Site: T106 Identified Species: 29.52
UniProt: Q00534 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.29
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00534 NP_001138778.1 326 36938 T106 E H V D Q D L T T Y L D K V P
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001116412 303 33725 R101 E H V D Q D L R T Y L D K A P
Dog Lupus familis XP_852360 326 36788 T106 E H V D Q D L T T Y L D K V P
Cat Felis silvestris
Mouse Mus musculus Q64261 326 37010 T106 E H V D Q D L T T Y L D K V P
Rat Rattus norvegicus P35426 303 33780 R101 E H I D Q D L R T Y L D K A P
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511310 202 22667
Chicken Gallus gallus P13863 303 34670 L91 S M D L K K Y L D T I P S G Q
Frog Xenopus laevis Q91727 319 35666 K101 E H V D Q D L K T Y L S K V P
Zebra Danio Brachydanio rerio NP_001137525 302 33962 T103 E H V D Q D L T T Y L E K A P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477196 317 36383 S118 E H V E Q D L S D L I D R L P
Honey Bee Apis mellifera XP_391955 457 50351 L246 R L D R G L T L W L V F E H V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999689 373 42086 L106 F E L V D Q D L A Q Y L E K C
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816 S93 D L K K F M D S C P E F A K N
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012 S93 D L K K H M D S T P D F S K D
Baker's Yeast Sacchar. cerevisiae P00546 298 34043 K96 E F L D L D L K R Y M E G I P
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 65.6 96.6 N.A. 96.3 65 N.A. 56.1 43.5 65.3 76 N.A. 42.6 37.6 N.A. 50.6
Protein Similarity: 100 N.A. 76 97.5 N.A. 98.1 76 N.A. 58.5 61.9 77.9 83.1 N.A. 63.7 50.5 N.A. 63
P-Site Identity: 100 N.A. 86.6 100 N.A. 100 80 N.A. 0 0 86.6 86.6 N.A. 53.3 0 N.A. 0
P-Site Similarity: 100 N.A. 86.6 100 N.A. 100 86.6 N.A. 0 13.3 86.6 93.3 N.A. 86.6 13.3 N.A. 13.3
Percent
Protein Identity: N.A. 44.4 N.A. 44.7 40.1 N.A.
Protein Similarity: N.A. 62.2 N.A. 62.2 59.8 N.A.
P-Site Identity: N.A. 0 N.A. 6.6 40 N.A.
P-Site Similarity: N.A. 13.3 N.A. 20 66.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 7 0 0 0 7 20 0 % A
% Cys: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 7 % C
% Asp: 14 0 14 54 7 60 20 0 14 0 7 40 0 0 7 % D
% Glu: 60 7 0 7 0 0 0 0 0 0 7 14 14 0 0 % E
% Phe: 7 7 0 0 7 0 0 0 0 0 0 20 0 0 0 % F
% Gly: 0 0 0 0 7 0 0 0 0 0 0 0 7 7 0 % G
% His: 0 54 0 0 7 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 7 0 0 0 0 0 0 0 14 0 0 7 0 % I
% Lys: 0 0 14 14 7 7 0 14 0 0 0 0 47 20 0 % K
% Leu: 0 20 14 7 7 7 60 20 0 14 47 7 0 7 0 % L
% Met: 0 7 0 0 0 14 0 0 0 0 7 0 0 0 0 % M
% Asn: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 7 % N
% Pro: 0 0 0 0 0 0 0 0 0 14 0 7 0 0 60 % P
% Gln: 0 0 0 0 54 7 0 0 0 7 0 0 0 0 7 % Q
% Arg: 7 0 0 7 0 0 0 14 7 0 0 0 7 0 0 % R
% Ser: 7 0 0 0 0 0 0 20 0 0 0 7 14 0 0 % S
% Thr: 0 0 0 0 0 0 7 27 54 7 0 0 0 0 0 % T
% Val: 0 0 47 7 0 0 0 0 0 0 7 0 0 27 7 % V
% Trp: 0 0 0 0 0 0 0 0 7 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 7 0 0 54 7 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _