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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
9.7
Human Site:
T267
Identified Species:
15.24
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
0.29
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
T267
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
P245
W
P
R
D
V
S
L
P
R
G
A
F
P
P
R
Dog
Lupus familis
XP_852360
326
36788
T267
Q
P
I
E
K
F
V
T
D
I
D
E
Q
G
K
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
T267
Q
P
I
E
K
F
V
T
D
I
D
E
L
G
K
Rat
Rattus norvegicus
P35426
303
33780
P245
W
P
R
E
V
S
L
P
R
G
A
F
S
P
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
D144
P
I
E
K
F
V
T
D
I
D
E
L
G
K
D
Chicken
Gallus gallus
P13863
303
34670
D236
P
D
V
E
S
L
Q
D
Y
K
N
T
F
P
K
Frog
Xenopus laevis
Q91727
319
35666
P245
W
P
V
D
V
T
L
P
R
S
A
F
S
P
R
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
Q243
P
S
P
E
D
W
P
Q
E
V
G
L
P
Q
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
T258
T
E
Q
Q
W
P
Q
T
I
S
V
A
L
E
H
Honey Bee
Apis mellifera
XP_391955
457
50351
V399
Q
G
E
W
P
E
N
V
S
L
S
W
T
A
F
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
Q267
R
S
F
L
D
L
V
Q
E
I
C
N
Q
G
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
D236
P
G
V
S
C
L
P
D
F
K
T
A
F
P
R
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
D236
R
G
V
T
S
L
P
D
Y
K
S
A
F
P
K
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
V240
E
A
I
W
P
D
I
V
Y
L
P
D
F
K
P
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
6.6
93.3
N.A.
100
13.3
N.A.
0
13.3
6.6
6.6
N.A.
13.3
6.6
N.A.
20
P-Site Similarity:
100
N.A.
26.6
93.3
N.A.
100
26.6
N.A.
13.3
26.6
33.3
26.6
N.A.
20
13.3
N.A.
33.3
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
0
N.A.
6.6
6.6
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
20
33.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
0
0
0
0
0
0
0
20
20
0
7
0
% A
% Cys:
0
0
0
0
7
0
0
0
0
0
7
0
0
0
0
% C
% Asp:
0
7
0
14
14
7
0
27
20
7
20
7
0
0
7
% D
% Glu:
7
7
14
40
0
7
0
0
14
0
7
20
0
7
0
% E
% Phe:
0
0
7
0
7
20
0
0
7
0
0
20
27
0
7
% F
% Gly:
0
20
0
0
0
0
0
0
0
14
7
0
7
27
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
7
% H
% Ile:
0
7
27
0
0
0
7
0
14
27
0
0
0
0
0
% I
% Lys:
0
0
0
7
20
0
0
0
0
20
0
0
0
14
34
% K
% Leu:
0
0
0
7
0
27
20
0
0
14
0
14
20
0
7
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
7
0
0
0
7
7
0
0
0
% N
% Pro:
27
40
7
0
14
7
20
20
0
0
7
0
14
40
7
% P
% Gln:
27
0
7
7
0
0
14
14
0
0
0
0
14
7
0
% Q
% Arg:
14
0
14
0
0
0
0
0
20
0
0
0
0
0
27
% R
% Ser:
0
14
0
7
14
14
0
0
7
14
14
0
14
0
7
% S
% Thr:
7
0
0
7
0
7
7
27
0
0
7
7
7
0
0
% T
% Val:
0
0
27
0
20
7
27
14
0
7
7
0
0
0
0
% V
% Trp:
20
0
0
14
7
7
0
0
0
0
0
7
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
20
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _