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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CDK6 All Species: 11.52
Human Site: T325 Identified Species: 18.1
UniProt: Q00534 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00534 NP_001138778.1 326 36938 T325 Q N T S E L N T A _ _ _ _ _ _
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta XP_001116412 303 33725
Dog Lupus familis XP_852360 326 36788 T325 Q N S S E M N T A _ _ _ _ _ _
Cat Felis silvestris
Mouse Mus musculus Q64261 326 37010 T325 Q S T S E L N T A _ _ _ _ _ _
Rat Rattus norvegicus P35426 303 33780
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001511310 202 22667
Chicken Gallus gallus P13863 303 34670 T294 F D D L D K S T L P A N L I K
Frog Xenopus laevis Q91727 319 35666 S303 A D D P Q A C S K Q E H F T H
Zebra Danio Brachydanio rerio NP_001137525 302 33962 A301 K P S L E E R A A _ _ _ _ _ _
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_477196 317 36383 P316 H D Y F Q Q E P L _ _ _ _ _ _
Honey Bee Apis mellifera XP_391955 457 50351
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus NP_999689 373 42086 D325 D D D E E D E D D E G V D V G
Poplar Tree Populus trichocarpa
Maize Zea mays P23111 294 33816
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P24100 294 34012
Baker's Yeast Sacchar. cerevisiae P00546 298 34043
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. 65.6 96.6 N.A. 96.3 65 N.A. 56.1 43.5 65.3 76 N.A. 42.6 37.6 N.A. 50.6
Protein Similarity: 100 N.A. 76 97.5 N.A. 98.1 76 N.A. 58.5 61.9 77.9 83.1 N.A. 63.7 50.5 N.A. 63
P-Site Identity: 100 N.A. 0 77.7 N.A. 88.8 0 N.A. 0 6.6 0 22.2 N.A. 0 0 N.A. 6.6
P-Site Similarity: 100 N.A. 0 100 N.A. 100 0 N.A. 0 33.3 20 44.4 N.A. 22.2 0 N.A. 26.6
Percent
Protein Identity: N.A. 44.4 N.A. 44.7 40.1 N.A.
Protein Similarity: N.A. 62.2 N.A. 62.2 59.8 N.A.
P-Site Identity: N.A. 0 N.A. 0 0 N.A.
P-Site Similarity: N.A. 0 N.A. 0 0 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 7 0 0 0 0 7 0 7 27 0 7 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % C
% Asp: 7 27 20 0 7 7 0 7 7 0 0 0 7 0 0 % D
% Glu: 0 0 0 7 34 7 14 0 0 7 7 0 0 0 0 % E
% Phe: 7 0 0 7 0 0 0 0 0 0 0 0 7 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 7 % G
% His: 7 0 0 0 0 0 0 0 0 0 0 7 0 0 7 % H
% Ile: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % I
% Lys: 7 0 0 0 0 7 0 0 7 0 0 0 0 0 7 % K
% Leu: 0 0 0 14 0 14 0 0 14 0 0 0 7 0 0 % L
% Met: 0 0 0 0 0 7 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 14 0 0 0 0 20 0 0 0 0 7 0 0 0 % N
% Pro: 0 7 0 7 0 0 0 7 0 7 0 0 0 0 0 % P
% Gln: 20 0 0 0 14 7 0 0 0 7 0 0 0 0 0 % Q
% Arg: 0 0 0 0 0 0 7 0 0 0 0 0 0 0 0 % R
% Ser: 0 7 14 20 0 0 7 7 0 0 0 0 0 0 0 % S
% Thr: 0 0 14 0 0 0 0 27 0 0 0 0 0 7 0 % T
% Val: 0 0 0 0 0 0 0 0 0 0 0 7 0 7 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 34 34 34 34 34 34 % _