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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
CDK6
All Species:
30.3
Human Site:
T95
Identified Species:
47.62
UniProt:
Q00534
Number Species:
14
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00534
NP_001138778.1
326
36938
T95
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001116412
303
33725
T90
T
D
R
E
I
K
V
T
L
V
F
E
H
V
D
Dog
Lupus familis
XP_852360
326
36788
T95
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Cat
Felis silvestris
Mouse
Mus musculus
Q64261
326
37010
T95
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Rat
Rattus norvegicus
P35426
303
33780
T90
T
D
R
D
I
K
V
T
L
V
F
E
H
I
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511310
202
22667
Chicken
Gallus gallus
P13863
303
34670
F80
D
A
R
L
Y
L
I
F
E
F
L
S
M
D
L
Frog
Xenopus laevis
Q91727
319
35666
T90
T
D
R
E
T
K
V
T
L
V
F
E
H
V
D
Zebra Danio
Brachydanio rerio
NP_001137525
302
33962
T92
T
D
R
E
T
K
L
T
L
V
F
E
H
V
D
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_477196
317
36383
L107
R
D
G
Q
L
L
I
L
L
V
F
E
H
V
E
Honey Bee
Apis mellifera
XP_391955
457
50351
G235
L
H
L
P
S
A
D
G
R
S
E
R
L
D
R
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
NP_999689
373
42086
L95
V
G
R
S
E
M
M
L
T
L
V
F
E
L
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
P23111
294
33816
Y82
R
I
Y
L
V
F
E
Y
L
D
L
D
L
K
K
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P24100
294
34012
Y82
R
L
Y
L
V
F
E
Y
L
D
L
D
L
K
K
Baker's Yeast
Sacchar. cerevisiae
P00546
298
34043
Y85
H
S
D
A
H
K
L
Y
L
V
F
E
F
L
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
65.6
96.6
N.A.
96.3
65
N.A.
56.1
43.5
65.3
76
N.A.
42.6
37.6
N.A.
50.6
Protein Similarity:
100
N.A.
76
97.5
N.A.
98.1
76
N.A.
58.5
61.9
77.9
83.1
N.A.
63.7
50.5
N.A.
63
P-Site Identity:
100
N.A.
86.6
100
N.A.
100
73.3
N.A.
0
6.6
93.3
100
N.A.
46.6
0
N.A.
6.6
P-Site Similarity:
100
N.A.
93.3
100
N.A.
100
93.3
N.A.
0
13.3
100
100
N.A.
66.6
6.6
N.A.
26.6
Percent
Protein Identity:
N.A.
44.4
N.A.
44.7
40.1
N.A.
Protein Similarity:
N.A.
62.2
N.A.
62.2
59.8
N.A.
P-Site Identity:
N.A.
6.6
N.A.
6.6
46.6
N.A.
P-Site Similarity:
N.A.
13.3
N.A.
13.3
53.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
7
0
7
0
7
0
0
0
0
0
0
0
0
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
7
54
7
7
0
0
7
0
0
14
0
14
0
14
54
% D
% Glu:
0
0
0
40
7
0
14
0
7
0
7
60
7
0
7
% E
% Phe:
0
0
0
0
0
14
0
7
0
7
60
7
7
0
0
% F
% Gly:
0
7
7
0
0
0
0
7
0
0
0
0
0
0
0
% G
% His:
7
7
0
0
7
0
0
0
0
0
0
0
54
0
0
% H
% Ile:
0
7
0
0
14
0
14
0
0
0
0
0
0
7
0
% I
% Lys:
0
0
0
0
0
54
0
0
0
0
0
0
0
14
14
% K
% Leu:
7
7
7
20
7
14
34
14
74
7
20
0
20
14
7
% L
% Met:
0
0
0
0
0
7
7
0
0
0
0
0
7
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
20
0
60
0
0
0
0
0
7
0
0
7
0
0
7
% R
% Ser:
0
7
0
7
7
0
0
0
0
7
0
7
0
0
0
% S
% Thr:
47
0
0
0
34
0
0
47
7
0
0
0
0
0
0
% T
% Val:
7
0
0
0
14
0
20
0
0
60
7
0
0
47
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
14
0
7
0
0
20
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _