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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CLTC All Species: 53.03
Human Site: Y754 Identified Species: 97.22
UniProt: Q00610 Number Species: 12
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00610 NP_004850.1 1675 191615 Y754 I C R E S N C Y D P E R V K N
Chimpanzee Pan troglodytes XP_001135961 1676 191711 Y755 I C R E S N C Y D P E R V K N
Rhesus Macaque Macaca mulatta XP_001108754 1682 192380 Y754 I C R E S N C Y D P E R V K N
Dog Lupus familis XP_537700 1675 191612 Y754 I C R E S N C Y D P E R V K N
Cat Felis silvestris
Mouse Mus musculus Q68FD5 1675 191538 Y754 I C R E S N C Y D P E R V K N
Rat Rattus norvegicus P11442 1675 191580 Y754 I C R E S N C Y D P E R V K N
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001509659 1675 191558 Y754 I C R E S N C Y D P E R V K N
Chicken Gallus gallus NP_001073586 1675 191592 Y754 I C R E S N C Y D P E R V K N
Frog Xenopus laevis NP_001085860 1675 191412 Y754 I S R E S N C Y D P E R V K N
Zebra Danio Brachydanio rerio XP_699126 1677 191618 Y754 I C R E S N C Y D P E R V K N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P29742 1678 191159 Y755 I C R E S N C Y N P E R V K N
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans P34574 1681 191524 Y756 I C R E S Q C Y D A E R V K N
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae P22137 1653 187216 Y760 I V K D N N V Y D P E R V K N
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.9 99.5 99.9 N.A. 99.8 99.7 N.A. 99.4 99.1 97.7 95.6 N.A. 79.6 N.A. 71.1 N.A.
Protein Similarity: 100 99.9 99.5 99.9 N.A. 99.9 99.8 N.A. 99.7 99.5 99.1 98 N.A. 90 N.A. 84.7 N.A.
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 100 100 93.3 100 N.A. 93.3 N.A. 86.6 N.A.
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 100 100 93.3 100 N.A. 100 N.A. 86.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. 49.6 N.A.
Protein Similarity: N.A. N.A. N.A. N.A. 69.7 N.A.
P-Site Identity: N.A. N.A. N.A. N.A. 66.6 N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. 86.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 0 8 0 0 0 0 0 % A
% Cys: 0 85 0 0 0 0 93 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 8 0 0 0 0 93 0 0 0 0 0 0 % D
% Glu: 0 0 0 93 0 0 0 0 0 0 100 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 100 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 8 0 0 0 0 0 0 0 0 0 0 100 0 % K
% Leu: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 8 93 0 0 8 0 0 0 0 0 100 % N
% Pro: 0 0 0 0 0 0 0 0 0 93 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % Q
% Arg: 0 0 93 0 0 0 0 0 0 0 0 100 0 0 0 % R
% Ser: 0 8 0 0 93 0 0 0 0 0 0 0 0 0 0 % S
% Thr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % T
% Val: 0 8 0 0 0 0 8 0 0 0 0 0 100 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 100 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _