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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: CACNA1B All Species: 13.64
Human Site: S2121 Identified Species: 30
UniProt: Q00975 Number Species: 10
    Phosphosite Substitution
    Charge Score: 0.3
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q00975 NP_000709.1 2339 262496 S2121 R R Q P S S S S S E K Q R F Y
Chimpanzee Pan troglodytes XP_520396 2784 310342 S2566 R R Q P S S S S S E K Q R F Y
Rhesus Macaque Macaca mulatta XP_001110352 2383 269535 D2145 S S I P S V S D T S T P R R S
Dog Lupus familis XP_537779 2046 229120 E1830 Q P S S S S S E K Q R F Y S C
Cat Felis silvestris
Mouse Mus musculus O55017 2327 261463 S2109 R R Q P S S S S S E K Q R F Y
Rat Rattus norvegicus Q02294 2336 262238 S2118 R R Q P S S S S S E K Q R F Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus O73700 2190 249326 H1973 I P L S P N F H H R T A L P L
Frog Xenopus laevis
Zebra Danio Brachydanio rerio Q2XVR3 1829 207718 L1613 L F D F V D A L Q E P L R I A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P91645 1851 212452 P1635 K R T Q L P Y P T Y G T T S L
Honey Bee Apis mellifera NP_001159376 1904 215872 H1688 P G Y D H H G H Y Y H E G P G
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus XP_001186699 1966 222605 D1750 Y V E F H D R D M Y D E P S Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 82.1 54.2 80.1 N.A. 91.9 92.1 N.A. N.A. 38.3 N.A. 20.7 N.A. 44.7 47.6 N.A. 39.5
Protein Similarity: 100 82.3 65.5 82.2 N.A. 94.4 94.5 N.A. N.A. 53.3 N.A. 36 N.A. 56 58.7 N.A. 52.4
P-Site Identity: 100 100 26.6 20 N.A. 100 100 N.A. N.A. 0 N.A. 13.3 N.A. 6.6 0 N.A. 6.6
P-Site Similarity: 100 100 33.3 40 N.A. 100 100 N.A. N.A. 6.6 N.A. 20 N.A. 20 6.6 N.A. 20
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 10 0 0 0 0 10 0 0 10 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 10 % C
% Asp: 0 0 10 10 0 19 0 19 0 0 10 0 0 0 0 % D
% Glu: 0 0 10 0 0 0 0 10 0 46 0 19 0 0 0 % E
% Phe: 0 10 0 19 0 0 10 0 0 0 0 10 0 37 0 % F
% Gly: 0 10 0 0 0 0 10 0 0 0 10 0 10 0 10 % G
% His: 0 0 0 0 19 10 0 19 10 0 10 0 0 0 0 % H
% Ile: 10 0 10 0 0 0 0 0 0 0 0 0 0 10 0 % I
% Lys: 10 0 0 0 0 0 0 0 10 0 37 0 0 0 0 % K
% Leu: 10 0 10 0 10 0 0 10 0 0 0 10 10 0 19 % L
% Met: 0 0 0 0 0 0 0 0 10 0 0 0 0 0 0 % M
% Asn: 0 0 0 0 0 10 0 0 0 0 0 0 0 0 0 % N
% Pro: 10 19 0 46 10 10 0 10 0 0 10 10 10 19 0 % P
% Gln: 10 0 37 10 0 0 0 0 10 10 0 37 0 0 0 % Q
% Arg: 37 46 0 0 0 0 10 0 0 10 10 0 55 10 0 % R
% Ser: 10 10 10 19 55 46 55 37 37 10 0 0 0 28 10 % S
% Thr: 0 0 10 0 0 0 0 0 19 0 19 10 10 0 0 % T
% Val: 0 10 0 0 10 10 0 0 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 10 0 10 0 0 0 10 0 10 28 0 0 10 0 46 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _