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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MDM2
All Species:
8.79
Human Site:
Y259
Identified Species:
21.48
UniProt:
Q00987
Number Species:
9
Phosphosite Substitution
Charge Score:
0.33
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q00987
NP_001138811.1
491
55233
Y259
E
S
L
D
S
E
D
Y
S
L
S
E
E
G
Q
Chimpanzee
Pan troglodytes
XP_001155208
497
56032
Y265
E
S
L
D
S
E
D
Y
S
L
S
E
E
G
Q
Rhesus Macaque
Macaca mulatta
XP_001117336
491
55228
Y259
E
S
L
D
S
E
D
Y
S
L
S
E
E
A
Q
Dog
Lupus familis
XP_536098
519
58173
A285
V
G
I
K
V
E
A
A
D
T
E
Q
T
S
E
Cat
Felis silvestris
Mouse
Mus musculus
P23804
489
54525
L259
L
D
S
E
D
Y
S
L
S
D
E
G
H
E
L
Rat
Rattus norvegicus
Q5XIN1
490
55202
A259
V
G
V
K
V
E
A
A
N
C
E
Q
P
S
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511571
475
53775
D262
Q
E
L
T
D
E
D
D
E
V
Y
Q
V
T
L
Chicken
Gallus gallus
XP_417957
481
54617
V264
E
T
A
D
C
E
E
V
K
E
G
D
K
K
V
Frog
Xenopus laevis
P56273
473
53446
E260
E
H
G
V
S
E
E
E
E
I
N
D
E
V
Y
Zebra Danio
Brachydanio rerio
O42354
445
49931
D245
A
Y
S
E
N
D
V
D
S
V
P
G
E
N
E
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
99.3
32.7
N.A.
81.4
32.5
N.A.
69.8
30.9
56.2
45.4
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
98.7
99.8
52.9
N.A.
87.7
52.5
N.A.
82.4
51.9
72.5
59.2
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
93.3
6.6
N.A.
6.6
6.6
N.A.
20
20
26.6
13.3
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
93.3
26.6
N.A.
13.3
33.3
N.A.
40
46.6
53.3
46.6
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
0
10
0
0
0
20
20
0
0
0
0
0
10
0
% A
% Cys:
0
0
0
0
10
0
0
0
0
10
0
0
0
0
0
% C
% Asp:
0
10
0
40
20
10
40
20
10
10
0
20
0
0
0
% D
% Glu:
50
10
0
20
0
80
20
10
20
10
30
30
50
10
30
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
20
10
0
0
0
0
0
0
0
10
20
0
20
0
% G
% His:
0
10
0
0
0
0
0
0
0
0
0
0
10
0
0
% H
% Ile:
0
0
10
0
0
0
0
0
0
10
0
0
0
0
0
% I
% Lys:
0
0
0
20
0
0
0
0
10
0
0
0
10
10
0
% K
% Leu:
10
0
40
0
0
0
0
10
0
30
0
0
0
0
20
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
0
0
0
10
0
10
0
0
10
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
0
30
0
0
30
% Q
% Arg:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% R
% Ser:
0
30
20
0
40
0
10
0
50
0
30
0
0
20
0
% S
% Thr:
0
10
0
10
0
0
0
0
0
10
0
0
10
10
0
% T
% Val:
20
0
10
10
20
0
10
10
0
20
0
0
10
10
10
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
10
0
0
0
10
0
30
0
0
10
0
0
0
10
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _