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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PDE1B
All Species:
21.52
Human Site:
S452
Identified Species:
47.33
UniProt:
Q01064
Number Species:
10
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01064
NP_000915.1
536
61380
S452
Q
P
L
A
D
E
D
S
K
S
K
N
Q
P
S
Chimpanzee
Pan troglodytes
XP_509115
536
61373
S452
Q
P
L
A
D
E
D
S
K
S
K
N
Q
P
S
Rhesus Macaque
Macaca mulatta
XP_001110208
536
61332
S452
Q
P
L
A
D
E
D
S
K
S
K
N
Q
P
S
Dog
Lupus familis
XP_852114
670
75871
R549
T
N
K
S
D
N
P
R
G
K
N
S
K
S
E
Cat
Felis silvestris
Mouse
Mus musculus
Q01065
535
61207
S451
Q
P
L
A
D
D
D
S
K
P
K
S
Q
P
S
Rat
Rattus norvegicus
Q01066
535
61241
S451
Q
P
L
T
D
D
D
S
K
S
K
S
Q
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001515772
621
69800
C448
V
P
L
I
E
E
S
C
R
S
E
S
S
C
L
Chicken
Gallus gallus
XP_418850
599
68575
S458
T
P
L
I
D
E
A
S
R
S
G
M
S
G
F
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
XP_001918973
762
86063
S512
T
P
L
I
E
E
A
S
P
A
G
L
A
G
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q8IRU4
662
72935
E564
Q
D
I
L
D
T
L
E
E
N
R
D
Y
Y
Q
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
O18696
664
74836
P562
E
P
L
V
S
L
P
P
T
D
S
L
F
P
P
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.4
97.9
50
N.A.
95.9
95.9
N.A.
52
55
N.A.
45.2
N.A.
28.2
N.A.
40.3
N.A.
Protein Similarity:
100
99.8
99.4
62.3
N.A.
98.1
98.3
N.A.
67.7
69.6
N.A.
57.4
N.A.
44.8
N.A.
55.2
N.A.
P-Site Identity:
100
100
100
6.6
N.A.
80
80
N.A.
26.6
40
N.A.
26.6
N.A.
13.3
N.A.
20
N.A.
P-Site Similarity:
100
100
100
26.6
N.A.
93.3
93.3
N.A.
53.3
46.6
N.A.
40
N.A.
46.6
N.A.
26.6
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
37
0
0
19
0
0
10
0
0
10
0
0
% A
% Cys:
0
0
0
0
0
0
0
10
0
0
0
0
0
10
0
% C
% Asp:
0
10
0
0
73
19
46
0
0
10
0
10
0
0
0
% D
% Glu:
10
0
0
0
19
55
0
10
10
0
10
0
0
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
10
0
19
% F
% Gly:
0
0
0
0
0
0
0
0
10
0
19
0
0
19
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
10
28
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
0
0
10
0
0
0
0
0
46
10
46
0
10
0
0
% K
% Leu:
0
0
82
10
0
10
10
0
0
0
0
19
0
0
10
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
10
0
0
0
% M
% Asn:
0
10
0
0
0
10
0
0
0
10
10
28
0
0
0
% N
% Pro:
0
82
0
0
0
0
19
10
10
10
0
0
0
55
10
% P
% Gln:
55
0
0
0
0
0
0
0
0
0
0
0
46
0
10
% Q
% Arg:
0
0
0
0
0
0
0
10
19
0
10
0
0
0
0
% R
% Ser:
0
0
0
10
10
0
10
64
0
55
10
37
19
10
46
% S
% Thr:
28
0
0
10
0
10
0
0
10
0
0
0
0
0
0
% T
% Val:
10
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
0
10
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _