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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: HMGCS1 All Species: 23.64
Human Site: S293 Identified Species: 34.67
UniProt: Q01581 Number Species: 15
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q01581 NP_001091742.1 520 57294 S293 D Q N R D K N S I Y S G L E A
Chimpanzee Pan troglodytes XP_517780 610 66491 S383 D Q N R D K N S I Y S G L E A
Rhesus Macaque Macaca mulatta XP_001090857 592 65050 S365 D Q N R D K N S I Y S G L E A
Dog Lupus familis XP_536483 637 69021 S410 D Q N R D K N S I Y S G L E A
Cat Felis silvestris
Mouse Mus musculus Q8JZK9 520 57550 S293 D Q N R D K N S I Y S G L E A
Rat Rattus norvegicus P17425 520 57415 S293 D Q N R D K N S I Y S G L E A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001506375 520 57160 E294 Q N K D M K T E L Y N G L E A
Chicken Gallus gallus P23228 522 57541 G294 Q N A E T A N G V F S G L E A
Frog Xenopus laevis NP_001087380 520 57303 G294 S N P N T E S G V Y V G L D S
Zebra Danio Brachydanio rerio NP_957379 508 55918 G283 P S P N M E S G P F S G L E A
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster NP_524711 465 51158 K241 Q Q Q K D T S K Q P A S L S T
Honey Bee Apis mellifera XP_397202 453 50855 V229 Y Q T Y R K K V I D K Y N H D
Nematode Worm Caenorhab. elegans P54871 462 51397 V238 Y T Y F I S K V N R H T T G I
Sea Urchin Strong. purpuratus XP_801879 508 56054 V280 Q K S L A R L V L N D F L H D
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P54873 461 51076 S237 K I E G K E F S I N D A D Y I
Baker's Yeast Sacchar. cerevisiae P54839 491 54995 K267 Q V Y K S Y S K K A I S K G L
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 85 87.3 78.6 N.A. 94.6 94.8 N.A. 90.1 83.9 80 77.6 N.A. 58 54.6 38.4 63.2
Protein Similarity: 100 85 87.3 80.5 N.A. 97.5 97.6 N.A. 95.3 91 88.6 87.1 N.A. 69.6 68.6 54.8 75.3
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 40 40 20 33.3 N.A. 20 20 0 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 53.3 53.3 53.3 53.3 N.A. 40 20 0 33.3
Percent
Protein Identity: N.A. N.A. N.A. 44 45.1 N.A.
Protein Similarity: N.A. N.A. N.A. 60.1 60.1 N.A.
P-Site Identity: N.A. N.A. N.A. 13.3 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 20 13.3 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 7 0 7 7 0 0 0 7 7 7 0 0 57 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 38 0 0 7 44 0 0 0 0 7 13 0 7 7 13 % D
% Glu: 0 0 7 7 0 19 0 7 0 0 0 0 0 57 0 % E
% Phe: 0 0 0 7 0 0 7 0 0 13 0 7 0 0 0 % F
% Gly: 0 0 0 7 0 0 0 19 0 0 0 63 0 13 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 7 0 0 13 0 % H
% Ile: 0 7 0 0 7 0 0 0 50 0 7 0 0 0 13 % I
% Lys: 7 7 7 13 7 50 13 13 7 0 7 0 7 0 0 % K
% Leu: 0 0 0 7 0 0 7 0 13 0 0 0 75 0 7 % L
% Met: 0 0 0 0 13 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 19 38 13 0 0 44 0 7 13 7 0 7 0 0 % N
% Pro: 7 0 13 0 0 0 0 0 7 7 0 0 0 0 0 % P
% Gln: 32 50 7 0 0 0 0 0 7 0 0 0 0 0 0 % Q
% Arg: 0 0 0 38 7 7 0 0 0 7 0 0 0 0 0 % R
% Ser: 7 7 7 0 7 7 25 44 0 0 50 13 0 7 7 % S
% Thr: 0 7 7 0 13 7 7 0 0 0 0 7 7 0 7 % T
% Val: 0 7 0 0 0 0 0 19 13 0 7 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 13 0 13 7 0 7 0 0 0 50 0 7 0 7 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _