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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
HMGCS1
All Species:
21.82
Human Site:
S447
Identified Species:
32
UniProt:
Q01581
Number Species:
15
Phosphosite Substitution
Charge Score:
0.2
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q01581
NP_001091742.1
520
57294
S447
I
P
Q
G
S
I
D
S
L
F
E
G
T
W
Y
Chimpanzee
Pan troglodytes
XP_517780
610
66491
S537
I
P
Q
G
S
I
D
S
L
F
E
G
T
W
Y
Rhesus Macaque
Macaca mulatta
XP_001090857
592
65050
S519
I
P
Q
G
S
I
D
S
L
F
E
G
T
W
Y
Dog
Lupus familis
XP_536483
637
69021
S564
I
P
Q
S
S
V
D
S
L
F
E
G
T
W
Y
Cat
Felis silvestris
Mouse
Mus musculus
Q8JZK9
520
57550
S447
I
P
Q
C
S
I
D
S
L
F
E
G
T
W
Y
Rat
Rattus norvegicus
P17425
520
57415
S447
I
P
Q
C
S
I
D
S
L
F
E
G
T
W
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506375
520
57160
G448
I
P
Q
S
S
V
D
G
L
F
E
G
T
W
Y
Chicken
Gallus gallus
P23228
522
57541
D448
I
P
Q
C
S
V
E
D
L
F
E
G
T
W
Y
Frog
Xenopus laevis
NP_001087380
520
57303
D448
V
P
Q
G
S
V
D
D
L
F
P
G
T
W
Y
Zebra Danio
Brachydanio rerio
NP_957379
508
55918
V435
N
Y
I
P
Q
G
S
V
D
E
L
F
P
G
T
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
NP_524711
465
51158
L393
F
E
K
F
V
S
Q
L
D
Y
V
Q
P
L
L
Honey Bee
Apis mellifera
XP_397202
453
50855
D381
K
D
Y
N
E
K
S
D
L
V
K
I
T
S
S
Nematode Worm
Caenorhab. elegans
P54871
462
51397
R390
V
A
I
R
A
I
K
R
L
D
D
R
I
Q
F
Sea Urchin
Strong. purpuratus
XP_801879
508
56054
L432
V
F
A
D
T
M
K
L
R
E
D
T
H
H
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P54873
461
51076
G389
I
A
S
V
M
D
V
G
G
K
L
K
A
R
H
Baker's Yeast
Sacchar. cerevisiae
P54839
491
54995
D419
Y
S
C
K
I
V
G
D
V
Q
H
I
I
K
E
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
85
87.3
78.6
N.A.
94.6
94.8
N.A.
90.1
83.9
80
77.6
N.A.
58
54.6
38.4
63.2
Protein Similarity:
100
85
87.3
80.5
N.A.
97.5
97.6
N.A.
95.3
91
88.6
87.1
N.A.
69.6
68.6
54.8
75.3
P-Site Identity:
100
100
100
86.6
N.A.
93.3
93.3
N.A.
80
73.3
73.3
0
N.A.
0
13.3
13.3
0
P-Site Similarity:
100
100
100
93.3
N.A.
93.3
93.3
N.A.
86.6
86.6
86.6
0
N.A.
13.3
20
40
26.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
44
45.1
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
60.1
60.1
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
13.3
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
13
7
0
7
0
0
0
0
0
0
0
7
0
0
% A
% Cys:
0
0
7
19
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
7
0
7
0
7
50
25
13
7
13
0
0
0
0
% D
% Glu:
0
7
0
0
7
0
7
0
0
13
50
0
0
0
7
% E
% Phe:
7
7
0
7
0
0
0
0
0
57
0
7
0
0
7
% F
% Gly:
0
0
0
25
0
7
7
13
7
0
0
57
0
7
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
7
0
7
7
7
% H
% Ile:
57
0
13
0
7
38
0
0
0
0
0
13
13
0
0
% I
% Lys:
7
0
7
7
0
7
13
0
0
7
7
7
0
7
0
% K
% Leu:
0
0
0
0
0
0
0
13
69
0
13
0
0
7
13
% L
% Met:
0
0
0
0
7
7
0
0
0
0
0
0
0
0
0
% M
% Asn:
7
0
0
7
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
57
0
7
0
0
0
0
0
0
7
0
13
0
0
% P
% Gln:
0
0
57
0
7
0
7
0
0
7
0
7
0
7
0
% Q
% Arg:
0
0
0
7
0
0
0
7
7
0
0
7
0
7
0
% R
% Ser:
0
7
7
13
57
7
13
38
0
0
0
0
0
7
7
% S
% Thr:
0
0
0
0
7
0
0
0
0
0
0
7
63
0
7
% T
% Val:
19
0
0
7
7
32
7
7
7
7
7
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
57
0
% W
% Tyr:
7
7
7
0
0
0
0
0
0
7
0
0
0
0
57
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _