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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: SLC6A3 All Species: 24.24
Human Site: Y548 Identified Species: 48.48
UniProt: Q01959 Number Species: 11
    Phosphosite Substitution
    Charge Score: -0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q01959 NP_001035.1 620 68495 Y548 V T F R P P H Y G A Y I F P D
Chimpanzee Pan troglodytes XP_001175202 689 74825 L569 V P S S P S L L T R A P E Q S
Rhesus Macaque Macaca mulatta Q9MYX0 630 70239 R564 L M S P P Q L R L F Q Y N Y P
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus Q61327 619 68787 Y547 V T F R P P H Y G A Y I F P D
Rat Rattus norvegicus P23977 619 68728 Y547 V T F R P P H Y G A Y I F P D
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001508462 865 94609 Y793 I N F K P L T Y D E Y I F P L
Chicken Gallus gallus NP_990047 635 71560 Y563 I N F K P L T Y D D Y T F P F
Frog Xenopus laevis A7Y2X0 790 87434 Y698 Y Q W E P M T Y G S Y H Y P S
Zebra Danio Brachydanio rerio NP_571830 629 70143 Y557 A T F N P P K Y G S Y Y F P T
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P51905 622 69307 G556 M G Y K E M L G E E Y Y Y P D
Honey Bee Apis mellifera NP_001139210 643 71921 Y532 M G Y E P L T Y E D Y V Y P V
Nematode Worm Caenorhab. elegans Q03614 615 69247 Y541 I N Y Q A L T Y Q D Y T Y P T
Sea Urchin Strong. purpuratus
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 77.5 47.9 N.A. N.A. 93.5 93.2 N.A. 50 67 35.8 78 N.A. 48.5 51.7 45.4 N.A.
Protein Similarity: 100 79.9 66.8 N.A. N.A. 96.4 96.2 N.A. 59.4 80.4 52.6 86.4 N.A. 68 68.2 62.9 N.A.
P-Site Identity: 100 13.3 6.6 N.A. N.A. 100 100 N.A. 46.6 40 33.3 60 N.A. 20 26.6 20 N.A.
P-Site Similarity: 100 13.3 13.3 N.A. N.A. 100 100 N.A. 60 53.3 53.3 66.6 N.A. 46.6 53.3 46.6 N.A.
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 9 0 0 0 9 0 0 0 0 25 9 0 0 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 17 25 0 0 0 0 34 % D
% Glu: 0 0 0 17 9 0 0 0 17 17 0 0 9 0 0 % E
% Phe: 0 0 50 0 0 0 0 0 0 9 0 0 50 0 9 % F
% Gly: 0 17 0 0 0 0 0 9 42 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 25 0 0 0 0 9 0 0 0 % H
% Ile: 25 0 0 0 0 0 0 0 0 0 0 34 0 0 0 % I
% Lys: 0 0 0 25 0 0 9 0 0 0 0 0 0 0 0 % K
% Leu: 9 0 0 0 0 34 25 9 9 0 0 0 0 0 9 % L
% Met: 17 9 0 0 0 17 0 0 0 0 0 0 0 0 0 % M
% Asn: 0 25 0 9 0 0 0 0 0 0 0 0 9 0 0 % N
% Pro: 0 9 0 9 84 34 0 0 0 0 0 9 0 84 9 % P
% Gln: 0 9 0 9 0 9 0 0 9 0 9 0 0 9 0 % Q
% Arg: 0 0 0 25 0 0 0 9 0 9 0 0 0 0 0 % R
% Ser: 0 0 17 9 0 9 0 0 0 17 0 0 0 0 17 % S
% Thr: 0 34 0 0 0 0 42 0 9 0 0 17 0 0 17 % T
% Val: 34 0 0 0 0 0 0 0 0 0 0 9 0 0 9 % V
% Trp: 0 0 9 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 9 0 25 0 0 0 0 75 0 0 84 25 34 9 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _