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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: DHODH All Species: 59.39
Human Site: T217 Identified Species: 87.11
UniProt: Q02127 Number Species: 15
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02127 NP_001352.2 395 42867 T217 V N V S S P N T A G L R S L Q
Chimpanzee Pan troglodytes XP_001171601 395 42934 T217 V N V S S P N T A G L R S L Q
Rhesus Macaque Macaca mulatta XP_001104448 395 42761 T217 V N V S S P N T A G L R S L Q
Dog Lupus familis XP_853399 414 44435 T236 V N V S S P N T A G L R S L Q
Cat Felis silvestris
Mouse Mus musculus O35435 395 42682 T217 V N V S S P N T A G L R S L Q
Rat Rattus norvegicus Q63707 395 42644 T217 V N V S S P N T A G L R S L Q
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505402 311 33595 V158 L R N L L T K V L K E R D S L
Chicken Gallus gallus NP_001006131 387 41379 T209 V N V S S P N T P G L R D L Q
Frog Xenopus laevis NP_001085026 404 43603 T217 I N V S S P N T P G L R N L Q
Zebra Danio Brachydanio rerio NP_001008608 407 43839 T216 V N V S S P N T P G L R D L Q
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P32748 405 44323 T221 I N V S S P N T K G L R D M Q
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans NP_491930 411 45667 T228 L N V S S P N T P G L R S M Q
Sea Urchin Strong. purpuratus XP_794275 377 40637 T214 I N V S S P N T P G L R A M Q
Poplar Tree Populus trichocarpa XP_002306374 457 48689 T277 I N V S S P N T P G L R M L Q
Maize Zea mays NP_001152058 469 49529 T289 I N I S S P N T P G L R K L Q
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P32746 460 48528 T280 I N V S S P N T A G L R M L Q
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.4 97.9 84.5 N.A. 87.5 88.6 N.A. 65.8 72.6 66.3 66.3 N.A. 47.9 N.A. 49.6 56.2
Protein Similarity: 100 99.7 98.9 88.8 N.A. 92.6 93.4 N.A. 73.1 81.2 82.4 79.6 N.A. 64.6 N.A. 66.9 73.1
P-Site Identity: 100 100 100 100 N.A. 100 100 N.A. 6.6 86.6 80 86.6 N.A. 73.3 N.A. 80 73.3
P-Site Similarity: 100 100 100 100 N.A. 100 100 N.A. 13.3 86.6 93.3 86.6 N.A. 86.6 N.A. 93.3 93.3
Percent
Protein Identity: 45 47.1 N.A. 46.9 N.A. N.A.
Protein Similarity: 61.2 60.9 N.A. 61.3 N.A. N.A.
P-Site Identity: 80 73.3 N.A. 86.6 N.A. N.A.
P-Site Similarity: 86.6 86.6 N.A. 93.3 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 44 0 0 0 7 0 0 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 25 0 0 % D
% Glu: 0 0 0 0 0 0 0 0 0 0 7 0 0 0 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 0 0 0 0 94 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 38 0 7 0 0 0 0 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 0 7 0 7 7 0 0 7 0 0 % K
% Leu: 13 0 0 7 7 0 0 0 7 0 94 0 0 75 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 13 19 0 % M
% Asn: 0 94 7 0 0 0 94 0 0 0 0 0 7 0 0 % N
% Pro: 0 0 0 0 0 94 0 0 44 0 0 0 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 94 % Q
% Arg: 0 7 0 0 0 0 0 0 0 0 0 100 0 0 0 % R
% Ser: 0 0 0 94 94 0 0 0 0 0 0 0 44 7 0 % S
% Thr: 0 0 0 0 0 7 0 94 0 0 0 0 0 0 0 % T
% Val: 50 0 88 0 0 0 0 7 0 0 0 0 0 0 0 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _