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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1B3
All Species:
33.33
Human Site:
T85
Identified Species:
66.67
UniProt:
Q02153
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02153
NP_000848.1
619
70514
T85
C
Q
E
S
G
Y
D
T
I
L
R
V
L
G
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O54865
620
70579
T85
C
Q
E
S
G
Y
D
T
I
L
R
V
L
G
S
Rat
Rattus norvegicus
P20595
619
70438
T85
C
Q
E
S
G
Y
D
T
I
L
R
V
L
G
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510819
683
77917
T108
C
Q
E
S
G
Y
D
T
I
L
R
V
L
G
S
Chicken
Gallus gallus
XP_420376
698
78758
T167
C
Q
E
S
G
Y
D
T
I
L
R
V
L
G
S
Frog
Xenopus laevis
NP_001085192
609
69543
T85
C
Q
E
S
G
Y
D
T
I
L
R
V
L
G
S
Zebra Danio
Brachydanio rerio
XP_001920263
608
69179
T85
C
Q
E
S
G
Y
D
T
I
L
R
V
L
G
S
Tiger Blowfish
Takifugu rubipres
NP_001027728
617
70218
T85
C
Q
E
S
G
Y
D
T
I
L
R
V
L
G
S
Fruit Fly
Dros. melanogaster
Q8INF0
947
105028
R84
V
G
Q
Y
G
Y
D
R
V
L
S
V
L
G
R
Honey Bee
Apis mellifera
NP_001011632
603
68286
K85
C
Q
D
S
G
Y
D
K
I
L
Q
V
L
G
A
Nematode Worm
Caenorhab. elegans
Q6DNF4
675
76632
D85
T
M
E
T
G
W
D
D
L
I
R
S
M
S
P
Sea Urchin
Strong. purpuratus
P16065
1125
126238
Y241
T
K
E
T
T
R
I
Y
V
F
F
G
D
A
S
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
N.A.
N.A.
98.7
98.8
N.A.
88.2
85.8
93.6
88
87.4
24.2
63.8
32.2
20.1
Protein Similarity:
100
N.A.
N.A.
N.A.
N.A.
99.3
99.5
N.A.
89.5
86.9
96.2
93.6
94
38.6
77.7
52.4
32.5
P-Site Identity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
100
100
100
100
100
46.6
73.3
26.6
13.3
P-Site Similarity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
100
100
100
100
100
60
93.3
60
33.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
0
0
0
0
0
0
0
9
9
% A
% Cys:
75
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
9
0
0
0
92
9
0
0
0
0
9
0
0
% D
% Glu:
0
0
84
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
9
9
0
0
0
0
% F
% Gly:
0
9
0
0
92
0
0
0
0
0
0
9
0
84
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
9
0
75
9
0
0
0
0
0
% I
% Lys:
0
9
0
0
0
0
0
9
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
9
84
0
0
84
0
0
% L
% Met:
0
9
0
0
0
0
0
0
0
0
0
0
9
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
9
% P
% Gln:
0
75
9
0
0
0
0
0
0
0
9
0
0
0
0
% Q
% Arg:
0
0
0
0
0
9
0
9
0
0
75
0
0
0
9
% R
% Ser:
0
0
0
75
0
0
0
0
0
0
9
9
0
9
75
% S
% Thr:
17
0
0
17
9
0
0
67
0
0
0
0
0
0
0
% T
% Val:
9
0
0
0
0
0
0
0
17
0
0
84
0
0
0
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
9
0
84
0
9
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _