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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: GUCY1B3 All Species: 17.27
Human Site: Y567 Identified Species: 34.55
UniProt: Q02153 Number Species: 11
    Phosphosite Substitution
    Charge Score: 0.09
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02153 NP_000848.1 619 70514 Y567 G K I N V S E Y T Y R C L M S
Chimpanzee Pan troglodytes
Rhesus Macaque Macaca mulatta
Dog Lupus familis
Cat Felis silvestris
Mouse Mus musculus O54865 620 70579 Y567 G K I N V S E Y T Y R C L M S
Rat Rattus norvegicus P20595 619 70438 Y567 G K I N V S E Y T Y R C L M S
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001510819 683 77917 Y590 G K I N V S E Y T Y R C L M T
Chicken Gallus gallus XP_420376 698 78758 I644 T T G E K G K I N V S E Y T Y
Frog Xenopus laevis NP_001085192 609 69543 E558 S R T E T T G E K G K I N V S
Zebra Danio Brachydanio rerio XP_001920263 608 69179 T555 N L T S R T E T T G E K G K I
Tiger Blowfish Takifugu rubipres NP_001027728 617 70218 V564 G E K G R I N V S E F T F R C
Fruit Fly Dros. melanogaster Q8INF0 947 105028 S562 M K V H I S E S T K V L I G P
Honey Bee Apis mellifera NP_001011632 603 68286 G551 T E T T G E P G K I N V S E D
Nematode Worm Caenorhab. elegans Q6DNF4 675 76632 N591 G R I H C S E N A K K C A E S
Sea Urchin Strong. purpuratus P16065 1125 126238 W1057 L R I H V S P W C K Q V L D K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 N.A. N.A. N.A. N.A. 98.7 98.8 N.A. 88.2 85.8 93.6 88 87.4 24.2 63.8 32.2 20.1
Protein Similarity: 100 N.A. N.A. N.A. N.A. 99.3 99.5 N.A. 89.5 86.9 96.2 93.6 94 38.6 77.7 52.4 32.5
P-Site Identity: 100 N.A. N.A. N.A. N.A. 100 100 N.A. 93.3 0 6.6 13.3 6.6 26.6 0 40 26.6
P-Site Similarity: 100 N.A. N.A. N.A. N.A. 100 100 N.A. 100 6.6 33.3 26.6 20 53.3 6.6 60 53.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 0 0 0 0 0 9 0 0 0 9 0 0 % A
% Cys: 0 0 0 0 9 0 0 0 9 0 0 42 0 0 9 % C
% Asp: 0 0 0 0 0 0 0 0 0 0 0 0 0 9 9 % D
% Glu: 0 17 0 17 0 9 59 9 0 9 9 9 0 17 0 % E
% Phe: 0 0 0 0 0 0 0 0 0 0 9 0 9 0 0 % F
% Gly: 50 0 9 9 9 9 9 9 0 17 0 0 9 9 0 % G
% His: 0 0 0 25 0 0 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 50 0 9 9 0 9 0 9 0 9 9 0 9 % I
% Lys: 0 42 9 0 9 0 9 0 17 25 17 9 0 9 9 % K
% Leu: 9 9 0 0 0 0 0 0 0 0 0 9 42 0 0 % L
% Met: 9 0 0 0 0 0 0 0 0 0 0 0 0 34 0 % M
% Asn: 9 0 0 34 0 0 9 9 9 0 9 0 9 0 0 % N
% Pro: 0 0 0 0 0 0 17 0 0 0 0 0 0 0 9 % P
% Gln: 0 0 0 0 0 0 0 0 0 0 9 0 0 0 0 % Q
% Arg: 0 25 0 0 17 0 0 0 0 0 34 0 0 9 0 % R
% Ser: 9 0 0 9 0 59 0 9 9 0 9 0 9 0 42 % S
% Thr: 17 9 25 9 9 17 0 9 50 0 0 9 0 9 9 % T
% Val: 0 0 9 0 42 0 0 9 0 9 9 17 0 9 0 % V
% Trp: 0 0 0 0 0 0 0 9 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 34 0 34 0 0 9 0 9 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _