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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY1B3
All Species:
13.33
Human Site:
Y569
Identified Species:
26.67
UniProt:
Q02153
Number Species:
11
Phosphosite Substitution
Charge Score:
-0.18
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02153
NP_000848.1
619
70514
Y569
I
N
V
S
E
Y
T
Y
R
C
L
M
S
P
E
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
O54865
620
70579
Y569
I
N
V
S
E
Y
T
Y
R
C
L
M
S
P
E
Rat
Rattus norvegicus
P20595
619
70438
Y569
I
N
V
S
E
Y
T
Y
R
C
L
M
S
P
E
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001510819
683
77917
Y592
I
N
V
S
E
Y
T
Y
R
C
L
M
T
S
D
Chicken
Gallus gallus
XP_420376
698
78758
V646
G
E
K
G
K
I
N
V
S
E
Y
T
Y
R
C
Frog
Xenopus laevis
NP_001085192
609
69543
G560
T
E
T
T
G
E
K
G
K
I
N
V
S
E
Y
Zebra Danio
Brachydanio rerio
XP_001920263
608
69179
G557
T
S
R
T
E
T
T
G
E
K
G
K
I
N
V
Tiger Blowfish
Takifugu rubipres
NP_001027728
617
70218
E566
K
G
R
I
N
V
S
E
F
T
F
R
C
L
Q
Fruit Fly
Dros. melanogaster
Q8INF0
947
105028
K564
V
H
I
S
E
S
T
K
V
L
I
G
P
N
Y
Honey Bee
Apis mellifera
NP_001011632
603
68286
I553
T
T
G
E
P
G
K
I
N
V
S
E
D
A
Y
Nematode Worm
Caenorhab. elegans
Q6DNF4
675
76632
K593
I
H
C
S
E
N
A
K
K
C
A
E
S
T
G
Sea Urchin
Strong. purpuratus
P16065
1125
126238
K1059
I
H
V
S
P
W
C
K
Q
V
L
D
K
L
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
N.A.
N.A.
98.7
98.8
N.A.
88.2
85.8
93.6
88
87.4
24.2
63.8
32.2
20.1
Protein Similarity:
100
N.A.
N.A.
N.A.
N.A.
99.3
99.5
N.A.
89.5
86.9
96.2
93.6
94
38.6
77.7
52.4
32.5
P-Site Identity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
80
0
6.6
13.3
0
20
0
33.3
26.6
P-Site Similarity:
100
N.A.
N.A.
N.A.
N.A.
100
100
N.A.
93.3
6.6
26.6
26.6
13.3
46.6
0
46.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
0
0
9
0
0
0
9
0
0
9
0
% A
% Cys:
0
0
9
0
0
0
9
0
0
42
0
0
9
0
9
% C
% Asp:
0
0
0
0
0
0
0
0
0
0
0
9
9
0
9
% D
% Glu:
0
17
0
9
59
9
0
9
9
9
0
17
0
9
25
% E
% Phe:
0
0
0
0
0
0
0
0
9
0
9
0
0
0
0
% F
% Gly:
9
9
9
9
9
9
0
17
0
0
9
9
0
0
17
% G
% His:
0
25
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
50
0
9
9
0
9
0
9
0
9
9
0
9
0
0
% I
% Lys:
9
0
9
0
9
0
17
25
17
9
0
9
9
0
0
% K
% Leu:
0
0
0
0
0
0
0
0
0
9
42
0
0
17
0
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
34
0
0
0
% M
% Asn:
0
34
0
0
9
9
9
0
9
0
9
0
0
17
0
% N
% Pro:
0
0
0
0
17
0
0
0
0
0
0
0
9
25
0
% P
% Gln:
0
0
0
0
0
0
0
0
9
0
0
0
0
0
9
% Q
% Arg:
0
0
17
0
0
0
0
0
34
0
0
9
0
9
0
% R
% Ser:
0
9
0
59
0
9
9
0
9
0
9
0
42
9
0
% S
% Thr:
25
9
9
17
0
9
50
0
0
9
0
9
9
9
0
% T
% Val:
9
0
42
0
0
9
0
9
9
17
0
9
0
0
9
% V
% Trp:
0
0
0
0
0
9
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
34
0
34
0
0
9
0
9
0
25
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _