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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: ALDH6A1 All Species: 25.15
Human Site: S31 Identified Species: 42.56
UniProt: Q02252 Number Species: 13
    Phosphosite Substitution
    Charge Score: 0
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02252 NP_005580.1 535 57840 S31 S P T W Y S A S S F S S S V P
Chimpanzee Pan troglodytes XP_522903 535 57840 S31 S P T W Y S A S S F S S S V P
Rhesus Macaque Macaca mulatta XP_001093055 537 57955 S33 N S A W Y S A S S F S S S V P
Dog Lupus familis XP_547901 533 57750 Y29 N S T W Y P A Y S F S S S V P
Cat Felis silvestris
Mouse Mus musculus Q9EQ20 535 57897 S31 A T W Y P A S S F S S S S V P
Rat Rattus norvegicus Q02253 535 57789 S31 S T W Y P A S S F S S S S V P
Wallaby Macropus eugenll
Platypus Ornith. anatinus
Chicken Gallus gallus XP_421260 538 58274 A34 V P W I A S A A A S S S S V P
Frog Xenopus laevis NP_001089889 523 56695 A23 Q A N F S S S A A V P R T K L
Zebra Danio Brachydanio rerio NP_001002374 525 57101 M21 V P L Q V G R M C Y S S S V P
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q7KW39 520 55954 S21 L A K R S Y S S A A P T T K L
Honey Bee Apis mellifera XP_393234 520 56023 S22 A A R T Y S S S I P T V K M Y
Nematode Worm Caenorhab. elegans P52713 523 56443 S21 Q L A H F S T S K S A A A A P
Sea Urchin Strong. purpuratus XP_783603 565 61106 H62 P M S T K P D H I I D N C D P
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana Q0WM29 607 65908 S105 L S T S P E Q S T Q P Q M P P
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 99.8 97.5 95.8 N.A. 94.7 95.3 N.A. N.A. 83.6 79.8 80.5 N.A. 65 60.1 65 67
Protein Similarity: 100 99.8 98.5 98.5 N.A. 98.5 98.5 N.A. N.A. 91.8 92.3 89.9 N.A. 82.2 80 80 79.8
P-Site Identity: 100 100 80 73.3 N.A. 40 46.6 N.A. N.A. 53.3 6.6 40 N.A. 6.6 20 20 6.6
P-Site Similarity: 100 100 86.6 80 N.A. 66.6 66.6 N.A. N.A. 66.6 40 46.6 N.A. 33.3 46.6 46.6 20
Percent
Protein Identity: N.A. N.A. N.A. 51.2 N.A. N.A.
Protein Similarity: N.A. N.A. N.A. 68.2 N.A. N.A.
P-Site Identity: N.A. N.A. N.A. 20 N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 15 22 15 0 8 15 36 15 22 8 8 8 8 8 0 % A
% Cys: 0 0 0 0 0 0 0 0 8 0 0 0 8 0 0 % C
% Asp: 0 0 0 0 0 0 8 0 0 0 8 0 0 8 0 % D
% Glu: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % E
% Phe: 0 0 0 8 8 0 0 0 15 29 0 0 0 0 0 % F
% Gly: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 8 0 0 0 8 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 8 0 0 0 0 15 8 0 0 0 0 0 % I
% Lys: 0 0 8 0 8 0 0 0 8 0 0 0 8 15 0 % K
% Leu: 15 8 8 0 0 0 0 0 0 0 0 0 0 0 15 % L
% Met: 0 8 0 0 0 0 0 8 0 0 0 0 8 8 0 % M
% Asn: 15 0 8 0 0 0 0 0 0 0 0 8 0 0 0 % N
% Pro: 8 29 0 0 22 15 0 0 0 8 22 0 0 8 79 % P
% Gln: 15 0 0 8 0 0 8 0 0 8 0 8 0 0 0 % Q
% Arg: 0 0 8 8 0 0 8 0 0 0 0 8 0 0 0 % R
% Ser: 22 22 8 8 15 50 36 65 29 29 58 58 58 0 0 % S
% Thr: 0 15 29 15 0 0 8 0 8 0 8 8 15 0 0 % T
% Val: 15 0 0 0 8 0 0 0 0 8 0 8 0 58 0 % V
% Trp: 0 0 22 29 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 15 36 8 0 8 0 8 0 0 0 0 8 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _