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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
NRG1
All Species:
25.76
Human Site:
S629
Identified Species:
62.96
UniProt:
Q02297
Number Species:
9
Phosphosite Substitution
Charge Score:
0.11
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02297
NP_039256.2
640
70392
S629
E
E
I
Q
A
R
L
S
S
V
I
A
N
Q
D
Chimpanzee
Pan troglodytes
XP_001168800
640
70369
S629
E
E
I
Q
A
R
L
S
S
V
I
A
N
Q
D
Rhesus Macaque
Macaca mulatta
XP_001086071
640
70368
S629
E
E
I
Q
A
R
L
S
S
V
I
A
N
Q
D
Dog
Lupus familis
XP_858187
638
70094
S627
E
E
L
Q
A
R
L
S
S
V
I
A
N
Q
D
Cat
Felis silvestris
Mouse
Mus musculus
P56974
756
82195
D723
P
P
L
C
P
A
A
D
S
R
T
Y
Y
S
L
Rat
Rattus norvegicus
P43322
662
73270
S651
E
E
L
Q
A
R
L
S
S
V
I
A
N
Q
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508509
829
89843
S818
E
E
L
Q
A
R
L
S
S
V
I
A
N
Q
D
Chicken
Gallus gallus
Q05199
602
67435
V593
L
Q
A
R
L
S
S
V
I
A
N
Q
D
P
I
Frog
Xenopus laevis
O93383
677
75776
S655
E
E
L
Q
A
R
L
S
S
I
A
N
Q
A
L
Zebra Danio
Brachydanio rerio
NP_001038376
599
65205
M591
Q
N
R
L
T
A
V
M
A
N
Q
D
P
I
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
99.6
98.5
94
N.A.
33.2
88.2
N.A.
66
72.9
62.6
47.9
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
100
99.8
99.5
97.1
N.A.
48.5
91.9
N.A.
72.1
82
77
63.5
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
100
100
100
93.3
N.A.
6.6
93.3
N.A.
93.3
0
53.3
0
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
100
100
100
100
N.A.
13.3
100
N.A.
100
20
66.6
20
N.A.
N.A.
N.A.
N.A.
N.A.
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
10
0
70
20
10
0
10
10
10
60
0
10
10
% A
% Cys:
0
0
0
10
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
0
0
0
10
0
0
0
10
10
0
60
% D
% Glu:
70
70
0
0
0
0
0
0
0
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
30
0
0
0
0
0
10
10
60
0
0
10
10
% I
% Lys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% K
% Leu:
10
0
50
10
10
0
70
0
0
0
0
0
0
0
20
% L
% Met:
0
0
0
0
0
0
0
10
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
0
0
10
10
10
60
0
0
% N
% Pro:
10
10
0
0
10
0
0
0
0
0
0
0
10
10
0
% P
% Gln:
10
10
0
70
0
0
0
0
0
0
10
10
10
60
0
% Q
% Arg:
0
0
10
10
0
70
0
0
0
10
0
0
0
0
0
% R
% Ser:
0
0
0
0
0
10
10
70
80
0
0
0
0
10
0
% S
% Thr:
0
0
0
0
10
0
0
0
0
0
10
0
0
0
0
% T
% Val:
0
0
0
0
0
0
10
10
0
60
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
0
0
10
10
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _