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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
23.03
Human Site:
S299
Identified Species:
38.97
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
S299
T
P
G
R
P
L
S
S
Y
G
M
D
S
R
P
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
S299
T
P
G
R
P
L
S
S
Y
G
M
D
S
R
P
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
S299
T
P
G
R
P
L
S
S
Y
G
M
D
S
R
P
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
S299
T
P
G
R
P
L
S
S
Y
G
M
D
S
R
P
Rat
Rattus norvegicus
Q01986
393
43447
S299
T
P
G
R
P
L
S
S
Y
G
M
D
S
R
P
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
I315
I
F
E
L
L
D
Y
I
V
N
E
P
P
P
K
Chicken
Gallus gallus
Q90891
398
44059
G305
P
P
G
R
P
I
S
G
H
G
M
D
S
R
P
Frog
Xenopus laevis
Q05116
395
43724
S301
P
P
G
R
P
I
S
S
Y
G
P
D
S
R
P
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
I279
I
T
M
I
E
L
A
I
L
R
F
P
Y
D
S
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
I313
D
E
P
R
A
M
A
I
F
E
L
L
D
Y
I
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
Y298
D
S
L
E
E
P
N
Y
H
P
P
S
N
P
A
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
G315
I
R
K
T
R
V
G
G
V
F
S
D
S
P
R
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
D288
E
L
M
E
A
I
V
D
Q
P
P
P
A
L
P
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
K591
P
P
R
L
P
S
D
K
F
S
S
D
A
Q
D
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
100
100
N.A.
N.A.
100
100
N.A.
0
73.3
80
6.6
N.A.
6.6
N.A.
0
13.3
P-Site Similarity:
100
100
100
N.A.
N.A.
100
100
N.A.
0
86.6
86.6
13.3
N.A.
33.3
N.A.
20
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
6.6
20
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
0
15
0
15
0
0
0
0
0
15
0
8
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
15
0
0
0
0
8
8
8
0
0
0
65
8
8
8
% D
% Glu:
8
8
8
15
15
0
0
0
0
8
8
0
0
0
0
% E
% Phe:
0
8
0
0
0
0
0
0
15
8
8
0
0
0
0
% F
% Gly:
0
0
50
0
0
0
8
15
0
50
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
15
0
0
0
0
0
0
% H
% Ile:
22
0
0
8
0
22
0
22
0
0
0
0
0
0
8
% I
% Lys:
0
0
8
0
0
0
0
8
0
0
0
0
0
0
8
% K
% Leu:
0
8
8
15
8
43
0
0
8
0
8
8
0
8
0
% L
% Met:
0
0
15
0
0
8
0
0
0
0
43
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
8
0
0
8
0
0
8
0
0
% N
% Pro:
22
58
8
0
58
8
0
0
0
15
22
22
8
22
58
% P
% Gln:
0
0
0
0
0
0
0
0
8
0
0
0
0
8
0
% Q
% Arg:
0
8
8
58
8
0
0
0
0
8
0
0
0
50
8
% R
% Ser:
0
8
0
0
0
8
50
43
0
8
15
8
58
0
8
% S
% Thr:
36
8
0
8
0
0
0
0
0
0
0
0
0
0
0
% T
% Val:
0
0
0
0
0
8
8
0
15
0
0
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
8
8
43
0
0
0
8
8
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _