KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
|
Home
|
Kinexus
|
Contact
|
Credits
Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
MAP2K1
All Species:
31.82
Human Site:
S385
Identified Species:
53.85
UniProt:
Q02750
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02750
NP_002746.1
393
43439
S385
T
I
G
L
N
Q
P
S
T
P
T
H
A
A
G
Chimpanzee
Pan troglodytes
Q9XT09
393
43428
S385
T
I
G
L
N
Q
P
S
T
P
T
H
A
A
G
Rhesus Macaque
Macaca mulatta
XP_001110225
393
43444
S385
T
I
G
L
H
Q
P
S
T
P
T
H
A
A
G
Dog
Lupus familis
Cat
Felis silvestris
Mouse
Mus musculus
P31938
393
43456
S385
T
I
G
L
N
Q
P
S
T
P
T
H
A
A
S
Rat
Rattus norvegicus
Q01986
393
43447
S385
T
I
G
L
N
Q
P
S
T
P
T
H
A
A
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001511248
391
43070
S383
T
I
G
L
N
Q
P
S
T
P
T
H
A
A
G
Chicken
Gallus gallus
Q90891
398
44059
S391
T
L
R
L
N
Q
P
S
T
P
T
R
A
A
V
Frog
Xenopus laevis
Q05116
395
43724
S387
T
M
G
L
K
Q
P
S
T
P
T
H
A
A
G
Zebra Danio
Brachydanio rerio
Q9DGE0
361
40575
A352
D
S
K
D
T
D
V
A
S
F
V
K
T
I
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q24324
396
43851
T388
T
M
D
L
P
P
S
T
P
K
R
N
T
S
P
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q10664
387
42776
G370
Y
A
D
H
D
D
Q
G
E
F
A
V
F
V
K
Sea Urchin
Strong. purpuratus
XP_781505
412
45737
H401
T
M
G
M
S
P
P
H
N
D
T
V
K
P
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Q9S7U9
363
39830
N356
S
P
L
A
T
L
G
N
L
S
G
T
F
S
V
Baker's Yeast
Sacchar. cerevisiae
P08018
668
72701
V660
E
N
G
L
S
K
N
V
P
A
L
H
M
G
G
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.9
99.7
N.A.
N.A.
98.9
99.2
N.A.
73
81.6
91.9
33.3
N.A.
62.3
N.A.
52.4
64.8
Protein Similarity:
100
99.2
100
N.A.
N.A.
99.4
99.7
N.A.
77.8
88.9
96.1
51.4
N.A.
77.7
N.A.
69.2
75.7
P-Site Identity:
100
100
93.3
N.A.
N.A.
93.3
93.3
N.A.
100
73.3
86.6
0
N.A.
13.3
N.A.
0
26.6
P-Site Similarity:
100
100
100
N.A.
N.A.
93.3
93.3
N.A.
100
80
93.3
13.3
N.A.
40
N.A.
6.6
46.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
34.3
20.2
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
51.4
33.6
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
26.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
20
40
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
8
0
8
0
0
0
8
0
8
8
0
58
58
0
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
8
0
15
8
8
15
0
0
0
8
0
0
0
0
0
% D
% Glu:
8
0
0
0
0
0
0
0
8
0
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
0
0
0
0
15
0
0
15
0
0
% F
% Gly:
0
0
65
0
0
0
8
8
0
0
8
0
0
8
43
% G
% His:
0
0
0
8
8
0
0
8
0
0
0
58
0
0
0
% H
% Ile:
0
43
0
0
0
0
0
0
0
0
0
0
0
8
0
% I
% Lys:
0
0
8
0
8
8
0
0
0
8
0
8
8
0
8
% K
% Leu:
0
8
8
72
0
8
0
0
8
0
8
0
0
0
15
% L
% Met:
0
22
0
8
0
0
0
0
0
0
0
0
8
0
0
% M
% Asn:
0
8
0
0
43
0
8
8
8
0
0
8
0
0
0
% N
% Pro:
0
8
0
0
8
15
65
0
15
58
0
0
0
8
8
% P
% Gln:
0
0
0
0
0
58
8
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
8
0
0
0
0
0
0
0
8
8
0
0
0
% R
% Ser:
8
8
0
0
15
0
8
58
8
8
0
0
0
15
15
% S
% Thr:
72
0
0
0
15
0
0
8
58
0
65
8
15
0
0
% T
% Val:
0
0
0
0
0
0
8
8
0
0
8
15
0
8
15
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
8
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _