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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TEK All Species: 20
Human Site: Y1068 Identified Species: 36.67
UniProt: Q02763 Number Species: 12
    Phosphosite Substitution
    Charge Score: -0.08
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02763 NP_000450 1124 125830 Y1068 L N C D D E V Y D L M R Q C W
Chimpanzee Pan troglodytes XP_520519 1124 125727 Y1068 L N C D D E V Y D L M R Q C W
Rhesus Macaque Macaca mulatta XP_001105270 1124 125731 F1068 L N C D D E V F D L M R Q C W
Dog Lupus familis XP_539652 1239 135146 Y1184 R N C D D E V Y E L M R Q C W
Cat Felis silvestris
Mouse Mus musculus Q02858 1122 125682 Y1066 L N C D D E V Y D L M R Q C W
Rat Rattus norvegicus Q498D6 800 88690 L745 V E A L D K V L L A V S E E Y
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001505903 1124 124108 V1057 G L S R G Q E V Y V K K T M V
Chicken Gallus gallus P18460 806 89712 T751 R V L T M T S T D E Y L D L S
Frog Xenopus laevis O42127 802 89497 T747 R V L T V T S T N E Y L D L S
Zebra Danio Brachydanio rerio O73791 1116 122343 Y1060 L N C D D E V Y E L M Q Q C W
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster Q07407 729 82568 N674 M R Q C W H F N A D D R P P F
Honey Bee Apis mellifera XP_396649 796 90178 R741 W S Y Q P N E R P M F G E L V
Nematode Worm Caenorhab. elegans
Sea Urchin Strong. purpuratus Q26614 972 110463 S917 E D L D R I I S V S S N Q D Y
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana
Baker's Yeast Sacchar. cerevisiae
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.9 98.4 44 N.A. 92.7 25.7 N.A. 69.4 24.2 26.1 52.7 N.A. 23.9 25.2 N.A. 22.6
Protein Similarity: 100 99.1 99.1 57.9 N.A. 96 39.6 N.A. 77.8 40.2 40.7 67.9 N.A. 38.2 41 N.A. 39.5
P-Site Identity: 100 100 93.3 86.6 N.A. 100 13.3 N.A. 0 6.6 0 86.6 N.A. 6.6 0 N.A. 13.3
P-Site Similarity: 100 100 100 93.3 N.A. 100 46.6 N.A. 20 6.6 6.6 100 N.A. 20 20 N.A. 33.3
Percent
Protein Identity: N.A. N.A. N.A. N.A. N.A. N.A.
Protein Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Identity: N.A. N.A. N.A. N.A. N.A. N.A.
P-Site Similarity: N.A. N.A. N.A. N.A. N.A. N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 8 0 0 0 0 0 8 8 0 0 0 0 0 % A
% Cys: 0 0 47 8 0 0 0 0 0 0 0 0 0 47 0 % C
% Asp: 0 8 0 54 54 0 0 0 39 8 8 0 16 8 0 % D
% Glu: 8 8 0 0 0 47 16 0 16 16 0 0 16 8 0 % E
% Phe: 0 0 0 0 0 0 8 8 0 0 8 0 0 0 8 % F
% Gly: 8 0 0 0 8 0 0 0 0 0 0 8 0 0 0 % G
% His: 0 0 0 0 0 8 0 0 0 0 0 0 0 0 0 % H
% Ile: 0 0 0 0 0 8 8 0 0 0 0 0 0 0 0 % I
% Lys: 0 0 0 0 0 8 0 0 0 0 8 8 0 0 0 % K
% Leu: 39 8 24 8 0 0 0 8 8 47 0 16 0 24 0 % L
% Met: 8 0 0 0 8 0 0 0 0 8 47 0 0 8 0 % M
% Asn: 0 47 0 0 0 8 0 8 8 0 0 8 0 0 0 % N
% Pro: 0 0 0 0 8 0 0 0 8 0 0 0 8 8 0 % P
% Gln: 0 0 8 8 0 8 0 0 0 0 0 8 54 0 0 % Q
% Arg: 24 8 0 8 8 0 0 8 0 0 0 47 0 0 0 % R
% Ser: 0 8 8 0 0 0 16 8 0 8 8 8 0 0 16 % S
% Thr: 0 0 0 16 0 16 0 16 0 0 0 0 8 0 0 % T
% Val: 8 16 0 0 8 0 54 8 8 8 8 0 0 0 16 % V
% Trp: 8 0 0 0 8 0 0 0 0 0 0 0 0 0 47 % W
% Tyr: 0 0 8 0 0 0 0 39 8 0 16 0 0 0 16 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _