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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
GUCY2D
All Species:
16.97
Human Site:
S537
Identified Species:
37.33
UniProt:
Q02846
Number Species:
10
Phosphosite Substitution
Charge Score:
-0.1
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02846
NP_000171.1
1103
120059
S537
S
L
G
A
R
S
M
S
D
I
R
S
G
P
S
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
XP_001111670
1103
119842
S537
S
L
A
A
R
S
M
S
D
V
R
S
G
P
S
Dog
Lupus familis
XP_855577
1109
119381
S541
S
L
A
A
R
S
T
S
D
I
R
S
V
P
S
Cat
Felis silvestris
Mouse
Mus musculus
P52785
1108
120707
S540
S
L
A
T
R
S
A
S
D
I
R
S
V
P
S
Rat
Rattus norvegicus
P51840
1108
120782
S540
S
L
A
T
R
S
T
S
D
I
R
S
V
P
S
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001506097
1100
119406
G563
E
T
R
S
V
S
D
G
K
S
L
K
S
R
E
Chicken
Gallus gallus
XP_417281
1078
121075
T514
A
N
S
V
A
A
E
T
R
S
Q
K
S
T
I
Frog
Xenopus laevis
Zebra Danio
Brachydanio rerio
NP_571939
1107
124988
K545
S
K
S
Y
I
E
E
K
S
T
G
D
R
S
R
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Q07553
1163
130896
V512
V
D
M
K
D
V
T
V
I
N
L
G
E
Y
N
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q09435
1137
128085
S553
Q
V
R
G
K
G
A
S
R
R
S
L
Q
S
A
Sea Urchin
Strong. purpuratus
P16065
1125
126238
N478
E
A
L
D
E
D
A
N
V
L
K
P
V
W
H
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
97.5
81.8
N.A.
85.1
84.9
N.A.
50.9
53.1
N.A.
50.6
N.A.
28.3
N.A.
26.9
31.3
Protein Similarity:
100
N.A.
98.3
86.9
N.A.
90.1
89.7
N.A.
66.1
69.6
N.A.
68
N.A.
47.1
N.A.
44.4
47.2
P-Site Identity:
100
N.A.
86.6
80
N.A.
73.3
73.3
N.A.
6.6
0
N.A.
6.6
N.A.
0
N.A.
6.6
0
P-Site Similarity:
100
N.A.
93.3
80
N.A.
73.3
73.3
N.A.
13.3
26.6
N.A.
6.6
N.A.
6.6
N.A.
26.6
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
10
10
37
28
10
10
28
0
0
0
0
0
0
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
0
10
10
10
10
0
46
0
0
10
0
0
0
% D
% Glu:
19
0
0
0
10
10
19
0
0
0
0
0
10
0
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
0
10
10
0
10
0
10
0
0
10
10
19
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
10
% H
% Ile:
0
0
0
0
10
0
0
0
10
37
0
0
0
0
10
% I
% Lys:
0
10
0
10
10
0
0
10
10
0
10
19
0
0
0
% K
% Leu:
0
46
10
0
0
0
0
0
0
10
19
10
0
0
0
% L
% Met:
0
0
10
0
0
0
19
0
0
0
0
0
0
0
0
% M
% Asn:
0
10
0
0
0
0
0
10
0
10
0
0
0
0
10
% N
% Pro:
0
0
0
0
0
0
0
0
0
0
0
10
0
46
0
% P
% Gln:
10
0
0
0
0
0
0
0
0
0
10
0
10
0
0
% Q
% Arg:
0
0
19
0
46
0
0
0
19
10
46
0
10
10
10
% R
% Ser:
55
0
19
10
0
55
0
55
10
19
10
46
19
19
46
% S
% Thr:
0
10
0
19
0
0
28
10
0
10
0
0
0
10
0
% T
% Val:
10
10
0
10
10
10
0
10
10
10
0
0
37
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
10
0
% W
% Tyr:
0
0
0
10
0
0
0
0
0
0
0
0
0
10
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _