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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
24.55
Human Site:
S1131
Identified Species:
38.57
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
0.14
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S1131
T
Q
N
Q
H
D
D
S
S
S
D
S
G
T
P
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1139
T
Q
N
Q
H
D
D
S
S
S
D
S
G
T
P
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
S1125
T
Q
N
Q
H
D
D
S
S
S
D
S
G
T
P
Dog
Lupus familis
XP_534241
2041
231068
S1549
T
Q
N
Q
H
D
D
S
S
S
D
S
G
T
P
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
S1119
S
Q
N
Q
H
D
D
S
S
S
D
S
G
T
P
Rat
Rattus norvegicus
P41516
1526
173202
V1074
P
K
K
E
L
I
K
V
L
I
Q
R
G
Y
D
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
S1434
T
Q
N
Q
H
D
D
S
S
S
D
S
G
T
T
Chicken
Gallus gallus
O42131
1627
183228
A1136
P
Q
N
A
N
D
D
A
S
S
A
S
G
S
T
Frog
Xenopus laevis
NP_001082502
1579
178601
E1105
G
E
L
I
E
E
E
E
A
E
A
N
A
T
G
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
S1130
G
G
G
N
D
S
D
S
S
V
D
S
G
S
F
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
P995
N
N
C
L
R
R
F
P
T
A
I
D
I
L
K
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
Q1068
S
R
Q
E
K
Y
V
Q
R
K
E
Y
L
L
G
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
V996
D
T
T
V
K
F
V
V
K
M
N
E
D
R
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
E1021
D
L
R
F
E
Y
Y
E
K
R
K
E
T
V
V
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
V976
P
I
S
L
M
N
M
V
A
F
D
P
H
G
K
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
100
100
N.A.
93.3
6.6
N.A.
93.3
53.3
6.6
40
N.A.
0
N.A.
0
0
P-Site Similarity:
100
100
100
100
N.A.
100
20
N.A.
93.3
73.3
40
46.6
N.A.
13.3
N.A.
26.6
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
6.6
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
0
26.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
7
14
7
14
0
7
0
0
% A
% Cys:
0
0
7
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
14
0
0
0
7
47
54
0
0
0
54
7
7
0
7
% D
% Glu:
0
7
0
14
14
7
7
14
0
7
7
14
0
0
0
% E
% Phe:
0
0
0
7
0
7
7
0
0
7
0
0
0
0
7
% F
% Gly:
14
7
7
0
0
0
0
0
0
0
0
0
60
7
14
% G
% His:
0
0
0
0
40
0
0
0
0
0
0
0
7
0
0
% H
% Ile:
0
7
0
7
0
7
0
0
0
7
7
0
7
0
0
% I
% Lys:
0
7
7
0
14
0
7
0
14
7
7
0
0
0
14
% K
% Leu:
0
7
7
14
7
0
0
0
7
0
0
0
7
14
7
% L
% Met:
0
0
0
0
7
0
7
0
0
7
0
0
0
0
0
% M
% Asn:
7
7
47
7
7
7
0
0
0
0
7
7
0
0
0
% N
% Pro:
20
0
0
0
0
0
0
7
0
0
0
7
0
0
34
% P
% Gln:
0
47
7
40
0
0
0
7
0
0
7
0
0
0
0
% Q
% Arg:
0
7
7
0
7
7
0
0
7
7
0
7
0
7
0
% R
% Ser:
14
0
7
0
0
7
0
47
54
47
0
54
0
14
0
% S
% Thr:
34
7
7
0
0
0
0
0
7
0
0
0
7
47
14
% T
% Val:
0
0
0
7
0
0
14
20
0
7
0
0
0
7
7
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
14
7
0
0
0
0
7
0
7
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _