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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
TOP2B
All Species:
4.55
Human Site:
S1201
Identified Species:
7.14
UniProt:
Q02880
Number Species:
14
Phosphosite Substitution
Charge Score:
-0.07
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q02880
NP_001059.2
1626
183267
S1201
E
E
L
D
K
V
E
S
Q
E
R
E
D
V
L
Chimpanzee
Pan troglodytes
XP_516332
1634
184611
S1209
E
E
L
D
K
V
E
S
Q
E
R
E
D
V
L
Rhesus Macaque
Macaca mulatta
XP_001092092
1620
182490
A1195
E
E
L
D
K
V
E
A
Q
E
R
E
D
I
L
Dog
Lupus familis
XP_534241
2041
231068
A1619
E
E
L
D
K
V
E
A
Q
E
R
E
D
I
L
Cat
Felis silvestris
Mouse
Mus musculus
Q64511
1612
181890
A1189
E
E
L
D
K
V
E
A
Q
E
R
E
D
I
L
Rat
Rattus norvegicus
P41516
1526
173202
L1130
N
Y
L
L
D
M
P
L
W
Y
L
T
K
E
K
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507216
1923
216719
A1504
E
E
L
D
K
V
E
A
Q
E
R
E
D
I
L
Chicken
Gallus gallus
O42131
1627
183228
A1206
E
E
L
E
K
V
E
A
Q
E
R
E
D
V
L
Frog
Xenopus laevis
NP_001082502
1579
178601
A1173
D
E
L
D
S
L
E
A
K
E
R
E
E
E
S
Zebra Danio
Brachydanio rerio
NP_001038656
1618
182448
E1200
E
E
L
D
R
V
E
E
Q
E
K
E
S
V
N
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P15348
1447
164377
Q1051
K
L
V
V
E
N
K
Q
R
K
A
M
C
D
E
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Q23670
1520
172316
K1124
K
F
D
A
D
P
V
K
K
W
K
E
E
Q
K
Sea Urchin
Strong. purpuratus
XP_783546
1448
163750
L1052
I
L
R
E
F
F
T
L
R
M
E
L
Y
H
K
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
P30182
1473
164089
R1077
K
G
F
T
P
F
P
R
K
A
E
S
V
E
A
Baker's Yeast
Sacchar. cerevisiae
P06786
1428
164196
M1032
F
Q
V
K
F
I
K
M
I
I
E
K
E
L
T
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
98.3
98.5
78.1
N.A.
95.6
66.2
N.A.
79.3
89.2
66.6
73.6
N.A.
50.3
N.A.
49.5
57.3
Protein Similarity:
100
98.5
99.1
78.8
N.A.
97.2
78.1
N.A.
81.8
93.8
78.7
83.8
N.A.
64.3
N.A.
65.8
69.9
P-Site Identity:
100
100
86.6
86.6
N.A.
86.6
6.6
N.A.
86.6
86.6
46.6
66.6
N.A.
0
N.A.
6.6
0
P-Site Similarity:
100
100
100
100
N.A.
100
13.3
N.A.
100
100
80
80
N.A.
40
N.A.
33.3
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
43.3
40.7
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
59
56.8
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
0
0
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
13.3
46.6
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
0
7
0
0
0
40
0
7
7
0
0
0
7
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
7
0
0
% C
% Asp:
7
0
7
54
14
0
0
0
0
0
0
0
47
7
0
% D
% Glu:
54
60
0
14
7
0
60
7
0
60
20
67
20
20
7
% E
% Phe:
7
7
7
0
14
14
0
0
0
0
0
0
0
0
0
% F
% Gly:
0
7
0
0
0
0
0
0
0
0
0
0
0
0
0
% G
% His:
0
0
0
0
0
0
0
0
0
0
0
0
0
7
0
% H
% Ile:
7
0
0
0
0
7
0
0
7
7
0
0
0
27
0
% I
% Lys:
20
0
0
7
47
0
14
7
20
7
14
7
7
0
20
% K
% Leu:
0
14
67
7
0
7
0
14
0
0
7
7
0
7
47
% L
% Met:
0
0
0
0
0
7
0
7
0
7
0
7
0
0
0
% M
% Asn:
7
0
0
0
0
7
0
0
0
0
0
0
0
0
7
% N
% Pro:
0
0
0
0
7
7
14
0
0
0
0
0
0
0
0
% P
% Gln:
0
7
0
0
0
0
0
7
54
0
0
0
0
7
0
% Q
% Arg:
0
0
7
0
7
0
0
7
14
0
54
0
0
0
0
% R
% Ser:
0
0
0
0
7
0
0
14
0
0
0
7
7
0
7
% S
% Thr:
0
0
0
7
0
0
7
0
0
0
0
7
0
0
7
% T
% Val:
0
0
14
7
0
54
7
0
0
0
0
0
7
27
0
% V
% Trp:
0
0
0
0
0
0
0
0
7
7
0
0
0
0
0
% W
% Tyr:
0
7
0
0
0
0
0
0
0
7
0
0
7
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _