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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 4.55
Human Site: S1201 Identified Species: 7.14
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: -0.07
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 S1201 E E L D K V E S Q E R E D V L
Chimpanzee Pan troglodytes XP_516332 1634 184611 S1209 E E L D K V E S Q E R E D V L
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 A1195 E E L D K V E A Q E R E D I L
Dog Lupus familis XP_534241 2041 231068 A1619 E E L D K V E A Q E R E D I L
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 A1189 E E L D K V E A Q E R E D I L
Rat Rattus norvegicus P41516 1526 173202 L1130 N Y L L D M P L W Y L T K E K
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 A1504 E E L D K V E A Q E R E D I L
Chicken Gallus gallus O42131 1627 183228 A1206 E E L E K V E A Q E R E D V L
Frog Xenopus laevis NP_001082502 1579 178601 A1173 D E L D S L E A K E R E E E S
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 E1200 E E L D R V E E Q E K E S V N
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 Q1051 K L V V E N K Q R K A M C D E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 K1124 K F D A D P V K K W K E E Q K
Sea Urchin Strong. purpuratus XP_783546 1448 163750 L1052 I L R E F F T L R M E L Y H K
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 R1077 K G F T P F P R K A E S V E A
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 M1032 F Q V K F I K M I I E K E L T
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 86.6 86.6 N.A. 86.6 6.6 N.A. 86.6 86.6 46.6 66.6 N.A. 0 N.A. 6.6 0
P-Site Similarity: 100 100 100 100 N.A. 100 13.3 N.A. 100 100 80 80 N.A. 40 N.A. 33.3 13.3
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 0 N.A.
P-Site Similarity: N.A. N.A. N.A. 13.3 46.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 0 0 40 0 7 7 0 0 0 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 7 0 0 % C
% Asp: 7 0 7 54 14 0 0 0 0 0 0 0 47 7 0 % D
% Glu: 54 60 0 14 7 0 60 7 0 60 20 67 20 20 7 % E
% Phe: 7 7 7 0 14 14 0 0 0 0 0 0 0 0 0 % F
% Gly: 0 7 0 0 0 0 0 0 0 0 0 0 0 0 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 7 0 0 0 0 7 0 0 7 7 0 0 0 27 0 % I
% Lys: 20 0 0 7 47 0 14 7 20 7 14 7 7 0 20 % K
% Leu: 0 14 67 7 0 7 0 14 0 0 7 7 0 7 47 % L
% Met: 0 0 0 0 0 7 0 7 0 7 0 7 0 0 0 % M
% Asn: 7 0 0 0 0 7 0 0 0 0 0 0 0 0 7 % N
% Pro: 0 0 0 0 7 7 14 0 0 0 0 0 0 0 0 % P
% Gln: 0 7 0 0 0 0 0 7 54 0 0 0 0 7 0 % Q
% Arg: 0 0 7 0 7 0 0 7 14 0 54 0 0 0 0 % R
% Ser: 0 0 0 0 7 0 0 14 0 0 0 7 7 0 7 % S
% Thr: 0 0 0 7 0 0 7 0 0 0 0 7 0 0 7 % T
% Val: 0 0 14 7 0 54 7 0 0 0 0 0 7 27 0 % V
% Trp: 0 0 0 0 0 0 0 0 7 7 0 0 0 0 0 % W
% Tyr: 0 7 0 0 0 0 0 0 0 7 0 0 7 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _