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Updated: 2017 Aug. 1

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Warning – Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite   Conservation Score
Human Protein: TOP2B All Species: 28.48
Human Site: S1400 Identified Species: 44.76
UniProt: Q02880 Number Species: 14
    Phosphosite Substitution
    Charge Score: 0.36
Phosphosite
Sequences
Species Species
Scientific Name
UniProt ID NCBI Ref Seq ID AA# Mr(Da) P-Site -7 -6 -5 -4 -3 -2 -1 0 1 2 3 4 5 6 7
Human Homo sapiens Q02880 NP_001059.2 1626 183267 S1400 E E L K V K A S P I T N D G E
Chimpanzee Pan troglodytes XP_516332 1634 184611 S1408 E E L K V K A S P I T N D G E
Rhesus Macaque Macaca mulatta XP_001092092 1620 182490 S1394 E E L K V K A S P I T N D G E
Dog Lupus familis XP_534241 2041 231068 S1817 E E L K V K A S P I T N D G E
Cat Felis silvestris
Mouse Mus musculus Q64511 1612 181890 S1387 E E L K V K A S P I T N D G E
Rat Rattus norvegicus P41516 1526 173202 E1310 N F D V P P R E K E P R I A A
Wallaby Macropus eugenll
Platypus Ornith. anatinus XP_001507216 1923 216719 S1700 D E L K V K S S P V T N D R E
Chicken Gallus gallus O42131 1627 183228 S1406 D E L K V K A S P V I N D R E
Frog Xenopus laevis NP_001082502 1579 178601 D1362 K S D S E F S D F N P K S D S
Zebra Danio Brachydanio rerio NP_001038656 1618 182448 E1392 E E E E D G D E E Q E N D A S
Tiger Blowfish Takifugu rubipres
Fruit Fly Dros. melanogaster P15348 1447 164377 P1231 F P D P D G E P V E F K I T E
Honey Bee Apis mellifera
Nematode Worm Caenorhab. elegans Q23670 1520 172316 E1304 R V K K E P K E P K E P K K V
Sea Urchin Strong. purpuratus XP_783546 1448 163750 T1232 K G K G S K I T K P R K Q K L
Poplar Tree Populus trichocarpa
Maize Zea mays
Rice Oryza sativa
Thale Cress Arabidopsis thaliana P30182 1473 164089 E1257 K K K A S E S E T T E A S H S
Baker's Yeast Sacchar. cerevisiae P06786 1428 164196 T1212 S K K N K K S T A R K G K K I
Red Bread Mold Neurospora crassa
Conservation
Percent
Protein Identity: 100 98.3 98.5 78.1 N.A. 95.6 66.2 N.A. 79.3 89.2 66.6 73.6 N.A. 50.3 N.A. 49.5 57.3
Protein Similarity: 100 98.5 99.1 78.8 N.A. 97.2 78.1 N.A. 81.8 93.8 78.7 83.8 N.A. 64.3 N.A. 65.8 69.9
P-Site Identity: 100 100 100 100 N.A. 100 0 N.A. 73.3 73.3 0 26.6 N.A. 6.6 N.A. 13.3 6.6
P-Site Similarity: 100 100 100 100 N.A. 100 0 N.A. 93.3 86.6 13.3 33.3 N.A. 6.6 N.A. 13.3 20
Percent
Protein Identity: N.A. N.A. N.A. 43.3 40.7 N.A.
Protein Similarity: N.A. N.A. N.A. 59 56.8 N.A.
P-Site Identity: N.A. N.A. N.A. 0 6.6 N.A.
P-Site Similarity: N.A. N.A. N.A. 26.6 26.6 N.A.
Phosphosite
Consensus
Position -7 -6 -5 -4 -3 -4 -5 0 +1 +2 +3 +4 +5 +6 +7
% Ala: 0 0 0 7 0 0 40 0 7 0 0 7 0 14 7 % A
% Cys: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % C
% Asp: 14 0 20 0 14 0 7 7 0 0 0 0 54 7 0 % D
% Glu: 40 54 7 7 14 7 7 27 7 14 20 0 0 0 54 % E
% Phe: 7 7 0 0 0 7 0 0 7 0 7 0 0 0 0 % F
% Gly: 0 7 0 7 0 14 0 0 0 0 0 7 0 34 0 % G
% His: 0 0 0 0 0 0 0 0 0 0 0 0 0 7 0 % H
% Ile: 0 0 0 0 0 0 7 0 0 34 7 0 14 0 7 % I
% Lys: 20 14 27 54 7 60 7 0 14 7 7 20 14 20 0 % K
% Leu: 0 0 47 0 0 0 0 0 0 0 0 0 0 0 7 % L
% Met: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % M
% Asn: 7 0 0 7 0 0 0 0 0 7 0 54 0 0 0 % N
% Pro: 0 7 0 7 7 14 0 7 54 7 14 7 0 0 0 % P
% Gln: 0 0 0 0 0 0 0 0 0 7 0 0 7 0 0 % Q
% Arg: 7 0 0 0 0 0 7 0 0 7 7 7 0 14 0 % R
% Ser: 7 7 0 7 14 0 27 47 0 0 0 0 14 0 20 % S
% Thr: 0 0 0 0 0 0 0 14 7 7 40 0 0 7 0 % T
% Val: 0 7 0 7 47 0 0 0 7 14 0 0 0 0 7 % V
% Trp: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % W
% Tyr: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % Y
% Spaces: 0 0 0 0 0 0 0 0 0 0 0 0 0 0 0 % _